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High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma

EGF-like domain 6 (EGFL6), a member of the epidermal growth factor (EGF) repeat protein superfamily, is a secreted protein that promotes endothelial cell migration and angiogenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of EGF...

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Autores principales: Chuang, Chun-Yi, Chen, Mu-Kuan, Hsieh, Ming-Ju, Yeh, Chia-Ming, Lin, Chiao-Wen, Yang, Wei-En, Yang, Shun-Fa, Chou, Ying-Erh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441033/
https://www.ncbi.nlm.nih.gov/pubmed/28539817
http://dx.doi.org/10.7150/ijms.18555
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author Chuang, Chun-Yi
Chen, Mu-Kuan
Hsieh, Ming-Ju
Yeh, Chia-Ming
Lin, Chiao-Wen
Yang, Wei-En
Yang, Shun-Fa
Chou, Ying-Erh
author_facet Chuang, Chun-Yi
Chen, Mu-Kuan
Hsieh, Ming-Ju
Yeh, Chia-Ming
Lin, Chiao-Wen
Yang, Wei-En
Yang, Shun-Fa
Chou, Ying-Erh
author_sort Chuang, Chun-Yi
collection PubMed
description EGF-like domain 6 (EGFL6), a member of the epidermal growth factor (EGF) repeat protein superfamily, is a secreted protein that promotes endothelial cell migration and angiogenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of EGFL6 in patients with oral squamous cell carcinoma (OSCC). We measured the plasma EGFL6 levels of 392 OSCC patients by using a commercial enzyme-linked immunosorbent assay. We also analyzed EGFL6 mRNA levels of 328 OSCC patients from The Cancer Genome Atlas (TCGA) dataset. The results showed that plasma EGFL6 levels were significantly higher in patients with OSCC than in healthy controls (p < 0.001). Similar results were observed for the TCGA bioinformatics database. Moreover, plasma EGFL6 levels were significantly higher in the patients with advanced T status (p = 0.002), distant metastasis (p = 0.001), and higher TNM stage (p=0.033). In conclusion, our results suggest that plasma level of EGFL6 may be useful to assess disease progression, and especially advanced T status and higher TNM stage in patients with OSCC.
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spelling pubmed-54410332017-05-24 High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma Chuang, Chun-Yi Chen, Mu-Kuan Hsieh, Ming-Ju Yeh, Chia-Ming Lin, Chiao-Wen Yang, Wei-En Yang, Shun-Fa Chou, Ying-Erh Int J Med Sci Research Paper EGF-like domain 6 (EGFL6), a member of the epidermal growth factor (EGF) repeat protein superfamily, is a secreted protein that promotes endothelial cell migration and angiogenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of EGFL6 in patients with oral squamous cell carcinoma (OSCC). We measured the plasma EGFL6 levels of 392 OSCC patients by using a commercial enzyme-linked immunosorbent assay. We also analyzed EGFL6 mRNA levels of 328 OSCC patients from The Cancer Genome Atlas (TCGA) dataset. The results showed that plasma EGFL6 levels were significantly higher in patients with OSCC than in healthy controls (p < 0.001). Similar results were observed for the TCGA bioinformatics database. Moreover, plasma EGFL6 levels were significantly higher in the patients with advanced T status (p = 0.002), distant metastasis (p = 0.001), and higher TNM stage (p=0.033). In conclusion, our results suggest that plasma level of EGFL6 may be useful to assess disease progression, and especially advanced T status and higher TNM stage in patients with OSCC. Ivyspring International Publisher 2017-04-08 /pmc/articles/PMC5441033/ /pubmed/28539817 http://dx.doi.org/10.7150/ijms.18555 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chuang, Chun-Yi
Chen, Mu-Kuan
Hsieh, Ming-Ju
Yeh, Chia-Ming
Lin, Chiao-Wen
Yang, Wei-En
Yang, Shun-Fa
Chou, Ying-Erh
High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_full High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_fullStr High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_full_unstemmed High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_short High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_sort high level of plasma egfl6 is associated with clinicopathological characteristics in patients with oral squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441033/
https://www.ncbi.nlm.nih.gov/pubmed/28539817
http://dx.doi.org/10.7150/ijms.18555
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