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Association between sarcopenia and hearing thresholds in postmenopausal women

Background: Given the association between metabolic disturbance and sarcopenia, sarcopenia may be intrinsically associated with the prevalence of HL. However, few studies describe the association between sarcopenia and HL. The aim of this study was to evaluate the clinical association between sarcop...

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Autores principales: Kang, Seok Hui, Jung, Da Jung, Cho, Kyu Hyang, Park, Jong Won, Lee, Kyu-Yup, Do, Jun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441039/
https://www.ncbi.nlm.nih.gov/pubmed/28539823
http://dx.doi.org/10.7150/ijms.18048
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author Kang, Seok Hui
Jung, Da Jung
Cho, Kyu Hyang
Park, Jong Won
Lee, Kyu-Yup
Do, Jun Young
author_facet Kang, Seok Hui
Jung, Da Jung
Cho, Kyu Hyang
Park, Jong Won
Lee, Kyu-Yup
Do, Jun Young
author_sort Kang, Seok Hui
collection PubMed
description Background: Given the association between metabolic disturbance and sarcopenia, sarcopenia may be intrinsically associated with the prevalence of HL. However, few studies describe the association between sarcopenia and HL. The aim of this study was to evaluate the clinical association between sarcopenia and HL in postmenopausal Korean women. Patients and Methods: A total of 4,038 women were ultimately included in this study. All participants were postmenopausal. Participants were divided into two groups based on criteria from the Foundation for the National Institute of Health Sarcopenia Project: a normal group (sarcopenia index ≥ 0.512) and a sarcopenia group (sarcopenia index < 0.512). Low-frequency (Low-Freq), mid-frequency (Mid-Freq), and high-frequency (High-Freq) values were obtained. The average hearing threshold (AHT) was calculated as the pure tone average at the 4 frequencies of 0.5 kHz, 1 kHz, 2 kHz, and 3 kHz. Mild HL was as an AHT of 24 to 40 dB; moderate-to-profound HL was defined as an AHT of 40 dB or greater. Results: Of the 4,038 participants, 272 (6.7%) were allocated to the sarcopenia group, leaving 3,766 (93.3%) in the normal group. The groups differed significantly in terms of having hypertension (775 [20.6%] vs. 108 [39.7%]; P < 0.001) or metabolic syndrome (817 [21.7%] vs. 110 [40.4%]; P < 0.001) in the normal and sarcopenia groups, respectively. Visceral fat area (cm(3)) in the normal and sarcopenia groups was 99.0 ± 21.9 cm(3) and 117.0 ± 21.8 cm(3) , respectively (P < 0.001). The hsCRP level was higher in the sarcopenia group than in the normal group. For univariate and multivariate analyses, all 4 hearing thresholds were higher in the sarcopenia group than in the normal group. In addition, linear regression analyses showed Low-Freq, Mid-Freq, and High-Freq to be inversely correlated with the sarcopenia index. The unadjusted OR for mild HL was 2.692 (95% CI, 1.963-3.692; P < 0.001) in the sarcopenia group relative to the normal group, with an adjusted OR of 1.584 (95% CI, 1.131-2.217; P = 0.007). The unadjusted OR for moderate-to-profound HL in the sarcopenia group relative to the normal group was 6.246 (95% CI, 4.530-8.612; P < 0.001); the adjusted OR was 2.667 (95% CI, 1.866-3.812; P < 0.001). Conclusion: Sarcopenia may be associated with HL. It may be beneficial to perform screening audiometry in patients with sarcopenia.
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spelling pubmed-54410392017-05-24 Association between sarcopenia and hearing thresholds in postmenopausal women Kang, Seok Hui Jung, Da Jung Cho, Kyu Hyang Park, Jong Won Lee, Kyu-Yup Do, Jun Young Int J Med Sci Research Paper Background: Given the association between metabolic disturbance and sarcopenia, sarcopenia may be intrinsically associated with the prevalence of HL. However, few studies describe the association between sarcopenia and HL. The aim of this study was to evaluate the clinical association between sarcopenia and HL in postmenopausal Korean women. Patients and Methods: A total of 4,038 women were ultimately included in this study. All participants were postmenopausal. Participants were divided into two groups based on criteria from the Foundation for the National Institute of Health Sarcopenia Project: a normal group (sarcopenia index ≥ 0.512) and a sarcopenia group (sarcopenia index < 0.512). Low-frequency (Low-Freq), mid-frequency (Mid-Freq), and high-frequency (High-Freq) values were obtained. The average hearing threshold (AHT) was calculated as the pure tone average at the 4 frequencies of 0.5 kHz, 1 kHz, 2 kHz, and 3 kHz. Mild HL was as an AHT of 24 to 40 dB; moderate-to-profound HL was defined as an AHT of 40 dB or greater. Results: Of the 4,038 participants, 272 (6.7%) were allocated to the sarcopenia group, leaving 3,766 (93.3%) in the normal group. The groups differed significantly in terms of having hypertension (775 [20.6%] vs. 108 [39.7%]; P < 0.001) or metabolic syndrome (817 [21.7%] vs. 110 [40.4%]; P < 0.001) in the normal and sarcopenia groups, respectively. Visceral fat area (cm(3)) in the normal and sarcopenia groups was 99.0 ± 21.9 cm(3) and 117.0 ± 21.8 cm(3) , respectively (P < 0.001). The hsCRP level was higher in the sarcopenia group than in the normal group. For univariate and multivariate analyses, all 4 hearing thresholds were higher in the sarcopenia group than in the normal group. In addition, linear regression analyses showed Low-Freq, Mid-Freq, and High-Freq to be inversely correlated with the sarcopenia index. The unadjusted OR for mild HL was 2.692 (95% CI, 1.963-3.692; P < 0.001) in the sarcopenia group relative to the normal group, with an adjusted OR of 1.584 (95% CI, 1.131-2.217; P = 0.007). The unadjusted OR for moderate-to-profound HL in the sarcopenia group relative to the normal group was 6.246 (95% CI, 4.530-8.612; P < 0.001); the adjusted OR was 2.667 (95% CI, 1.866-3.812; P < 0.001). Conclusion: Sarcopenia may be associated with HL. It may be beneficial to perform screening audiometry in patients with sarcopenia. Ivyspring International Publisher 2017-04-09 /pmc/articles/PMC5441039/ /pubmed/28539823 http://dx.doi.org/10.7150/ijms.18048 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Kang, Seok Hui
Jung, Da Jung
Cho, Kyu Hyang
Park, Jong Won
Lee, Kyu-Yup
Do, Jun Young
Association between sarcopenia and hearing thresholds in postmenopausal women
title Association between sarcopenia and hearing thresholds in postmenopausal women
title_full Association between sarcopenia and hearing thresholds in postmenopausal women
title_fullStr Association between sarcopenia and hearing thresholds in postmenopausal women
title_full_unstemmed Association between sarcopenia and hearing thresholds in postmenopausal women
title_short Association between sarcopenia and hearing thresholds in postmenopausal women
title_sort association between sarcopenia and hearing thresholds in postmenopausal women
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441039/
https://www.ncbi.nlm.nih.gov/pubmed/28539823
http://dx.doi.org/10.7150/ijms.18048
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