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Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results
Experimental modeling of traumatic brain injury (TBI) in animals has identified several potential means and interventions that might have beneficial applications for treating traumatic brain injury clinically. Several of these interventions have been applied and tried with humans that are at differe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441042/ https://www.ncbi.nlm.nih.gov/pubmed/28539826 http://dx.doi.org/10.7150/ijms.18075 |
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author | Nyanzu, Mark Siaw-Debrah, Felix Ni, Haoqi Xu, Zhu Wang, Hua Lin, Xiao Zhuge, Qichuan Huang, Lijie |
author_facet | Nyanzu, Mark Siaw-Debrah, Felix Ni, Haoqi Xu, Zhu Wang, Hua Lin, Xiao Zhuge, Qichuan Huang, Lijie |
author_sort | Nyanzu, Mark |
collection | PubMed |
description | Experimental modeling of traumatic brain injury (TBI) in animals has identified several potential means and interventions that might have beneficial applications for treating traumatic brain injury clinically. Several of these interventions have been applied and tried with humans that are at different phases of testing (completed, prematurely terminated and others in progress). The promising results achieved in the laboratory with animal models have not been replicated with human trails as expected. This review will highlight some insights and significance attained via laboratory animal modeling of TBI as well as factors that require incorporation into the experimental studies that could help in translating results from laboratory to the bedside. Major progress has been made due to laboratory studies; in explaining the mechanisms as well as pathophysiological features of brain damage after TBI. Attempts to intervene in the cascade of events occurring after TBI all rely heavily on the knowledge from basic laboratory investigations. In looking to discover treatment, this review will endeavor to sight and state some central discrepancies between laboratory models and clinical scenarios. |
format | Online Article Text |
id | pubmed-5441042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-54410422017-05-24 Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results Nyanzu, Mark Siaw-Debrah, Felix Ni, Haoqi Xu, Zhu Wang, Hua Lin, Xiao Zhuge, Qichuan Huang, Lijie Int J Med Sci Review Experimental modeling of traumatic brain injury (TBI) in animals has identified several potential means and interventions that might have beneficial applications for treating traumatic brain injury clinically. Several of these interventions have been applied and tried with humans that are at different phases of testing (completed, prematurely terminated and others in progress). The promising results achieved in the laboratory with animal models have not been replicated with human trails as expected. This review will highlight some insights and significance attained via laboratory animal modeling of TBI as well as factors that require incorporation into the experimental studies that could help in translating results from laboratory to the bedside. Major progress has been made due to laboratory studies; in explaining the mechanisms as well as pathophysiological features of brain damage after TBI. Attempts to intervene in the cascade of events occurring after TBI all rely heavily on the knowledge from basic laboratory investigations. In looking to discover treatment, this review will endeavor to sight and state some central discrepancies between laboratory models and clinical scenarios. Ivyspring International Publisher 2017-04-09 /pmc/articles/PMC5441042/ /pubmed/28539826 http://dx.doi.org/10.7150/ijms.18075 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Nyanzu, Mark Siaw-Debrah, Felix Ni, Haoqi Xu, Zhu Wang, Hua Lin, Xiao Zhuge, Qichuan Huang, Lijie Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title | Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title_full | Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title_fullStr | Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title_full_unstemmed | Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title_short | Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results |
title_sort | improving on laboratory traumatic brain injury models to achieve better results |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441042/ https://www.ncbi.nlm.nih.gov/pubmed/28539826 http://dx.doi.org/10.7150/ijms.18075 |
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