Cargando…

Isoprenoid biosynthesis in dandelion latex is enhanced by the overexpression of three key enzymes involved in the mevalonate pathway

BACKGROUND: Latex from the dandelion species Taraxacum brevicorniculatum contains many high-value isoprenoid end products, e.g. triterpenes and polyisoprenes such as natural rubber. The isopentenyl pyrophosphate units required as precursors for these isoprenoids are provided by the mevalonate (MVA)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pütter, Katharina M., van Deenen, Nicole, Unland, Kristina, Prüfer, Dirk, Schulze Gronover, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441070/ https://www.ncbi.nlm.nih.gov/pubmed/28532507 http://dx.doi.org/10.1186/s12870-017-1036-0

Ejemplares similares

Oxidosqualene Cyclase Knock-Down in Latex of Taraxacum koksaghyz Reduces Triterpenes in Roots and Separated Natural Rubber
por: van Deenen, Nicole, et al.
Publicado: (2019)

The enzymes OSC1 and CYP716A263 produce a high variety of triterpenoids in the latex of Taraxacum koksaghyz
por: Pütter, Katharina M., et al.
Publicado: (2019)

Development of rubber‐enriched dandelion varieties by metabolic engineering of the inulin pathway
por: Stolze, Anna, et al.
Publicado: (2017)

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz
por: Unland, Kristina, et al.
Publicado: (2018)

Overexpression of a pseudo-etiolated-in-light-like protein in Taraxacum koksaghyz leads to a pale green phenotype and enables transcriptome-based network analysis of photomorphogenesis and isoprenoid biosynthesis
por: Wolters, Silva Melissa, et al.
Publicado: (2023)

Upregulating the mevalonate pathway and repressing sterol synthesis in Saccharomyces cerevisiae enhances the production of triterpenes
por: Bröker, Jan Niklas, et al.
Publicado: (2018)

Five Questions about Non-Mevalonate Isoprenoid Biosynthesis
por: Odom, Audrey R.
Publicado: (2011)

Loss of function mutation of the Rapid Alkalinization Factor (RALF1)-like peptide in the dandelion Taraxacum koksaghyz entails a high-biomass taproot phenotype
por: Wieghaus, Annika, et al.
Publicado: (2019)

Comparative proteome and metabolome analyses of latex-exuding and non-exuding Taraxacum koksaghyz roots provide insights into laticifer biology
por: Benninghaus, Vincent Alexander, et al.
Publicado: (2020)

Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways
por: Movahedi, Ali, et al.
Publicado: (2022)

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway
por: Cárdenas, Pablo D., et al.
Publicado: (2016)

Microscopic and Transcriptomic Analysis of Pollination Processes in Self-Incompatible Taraxacum koksaghyz
por: Wollenweber, Tassilo Erik, et al.
Publicado: (2021)

On the Origin of Isoprenoid Biosynthesis
por: Hoshino, Yosuke, et al.
Publicado: (2018)

Negative Feedbacks by Isoprenoids on a Mevalonate Kinase Expressed in the Corpora Allata of Mosquitoes
por: Nyati, Pratik, et al.
Publicado: (2015)

Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs †
por: Chiarella, Emanuela, et al.
Publicado: (2022)

FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity
por: Wiesner, Jochen, et al.
Publicado: (2016)

Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts
por: Perello, Catalina, et al.
Publicado: (2016)

Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds
por: Tricarico, Paola Maura, et al.
Publicado: (2014)

Correction: Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts
por: Perello, Catalina, et al.
Publicado: (2022)

Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis
por: Healey, Gareth D., et al.
Publicado: (2016)

Metabolic enzyme clustering by coiled coils improves the biosynthesis of resveratrol and mevalonate
por: Fink, Tina, et al.
Publicado: (2020)

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
por: Alizadeh, Javad, et al.
Publicado: (2017)

Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz
por: Schmidt, Thomas, et al.
Publicado: (2010)

Mechanistic insights into the reductive dehydroxylation pathway for the biosynthesis of isoprenoids promoted by the IspH enzyme
por: Abdel-Azeim, Safwat, et al.
Publicado: (2015)

Combinatorial Metabolic Engineering in Saccharomyces cerevisiae for the Enhanced Production of the FPP-Derived Sesquiterpene Germacrene
por: Bröker, Jan Niklas, et al.
Publicado: (2020)

Engineering Isoprenoid Biosynthesis in Artemisia annua L. for the Production of Taxadiene: A Key Intermediate of Taxol
por: Li, Meiya, et al.
Publicado: (2015)

HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants
por: Krause, Toni, et al.
Publicado: (2023)

The Dandelion
Publicado: (1891)

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
por: Edwards, Rachel L., et al.
Publicado: (2017)

Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast
por: Cao, Xuan, et al.
Publicado: (2020)

Taraxacum brevicorniculatum rubber elongation factor TbREF associates with lipid droplets and affects lipid turn-over in yeast
por: Bröker, Jan Niklas, et al.
Publicado: (2018)

Human isoprenoid synthase enzymes as therapeutic targets
por: Park, Jaeok, et al.
Publicado: (2014)

Comparative Transcriptome Analysis in Taraxacum koksaghyz to Identify Genes that Determine Root Volume and Root Length
por: Wieghaus, Annika, et al.
Publicado: (2022)

Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae
por: Chemler, Joseph A, et al.
Publicado: (2006)

Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis
por: KUZUYAMA, Tomohisa, et al.
Publicado: (2012)

Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids
por: Zou, Huibin, et al.
Publicado: (2018)

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
por: Placido, Dante, et al.
Publicado: (2022)

Quantifying Isoprenoids in the Ergosterol Biosynthesis by Gas Chromatography–Mass Spectrometry
por: Liebl, Maximilian, et al.
Publicado: (2023)

HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways
por: Kang, Hyeji, et al.
Publicado: (2019)

12.2 Mevalonate kinase deficiency: Impaired isoprenoid synthesis induces IL-1beta production via activation of Rac1
por: Kuijk, LM, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_b6damgtd6v0n8m4unc8kis47sp