Recapitulating and Correcting Marfan Syndrome in a Cellular Model

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in FBN1 gene, which encodes a key extracellular matrix protein FIBRILLIN-1. The haplosufficiency of FBN1 has been implicated in pathogenesis of MFS with manifestations primarily in cardiovascular, muscular, and ocular tissues....

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Detalles Bibliográficos
Autores principales: Park, Jung Woo, Yan, Li, Stoddard, Chris, Wang, Xiaofang, Yue, Zhichao, Crandall, Leann, Robinson, Tiwanna, Chang, Yuxiao, Denton, Kyle, Li, Enqin, Jiang, Bin, Zhang, Zhenwu, Martins-Taylor, Kristen, Yee, Siu-Pok, Nie, Hong, Gu, Feng, Si, Wei, Xie, Ting, Yue, Lixia, Xu, Ren-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441176/
https://www.ncbi.nlm.nih.gov/pubmed/28539832
http://dx.doi.org/10.7150/ijbs.19517

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