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A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission

Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder are rare. We present a case of a 72-year-old man who presented with back pain and acute renal failure. Ultrasound showed a soft tissue mass in the base of the bladder causing bilateral ureteric obstruction. Subsequent biopsy of this...

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Autores principales: Chong, Vincent, Zwi, Jonathan, Hanning, Fritha, Lim, Remy, Williams, Andrew, Cadwallader, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441246/
https://www.ncbi.nlm.nih.gov/pubmed/28560016
http://dx.doi.org/10.1093/jscr/rjw179
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author Chong, Vincent
Zwi, Jonathan
Hanning, Fritha
Lim, Remy
Williams, Andrew
Cadwallader, Jon
author_facet Chong, Vincent
Zwi, Jonathan
Hanning, Fritha
Lim, Remy
Williams, Andrew
Cadwallader, Jon
author_sort Chong, Vincent
collection PubMed
description Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder are rare. We present a case of a 72-year-old man who presented with back pain and acute renal failure. Ultrasound showed a soft tissue mass in the base of the bladder causing bilateral ureteric obstruction. Subsequent biopsy of this mass demonstrated neuroendocrine carcinoma. He was commenced on neoadjuvant chemotherapy (carboplatin/etoposide) and proceeded to a radical cysto-prostatectomy. Histology revealed a LCNEC involving the bladder, T4a with invasion through to adipose tissue and posteriorly at perivesical resection margins. In addition, there was a Gleason score 9 prostatic adenocarcinoma, distinct from the neuroendocrine carcinoma. Following surgery, the patient developed gross local-regional recurrence and refused further systemic therapy. However, 1 year following referral to palliative care, a further CT-PET showed complete spontaneous remission of his disease. There are only few case reports of LCNEC of the urinary bladder therefore the pathogenesis and treatment protocol are still unclear. This case report highlights the unpredictable nature of this disease.
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spelling pubmed-54412462017-05-30 A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission Chong, Vincent Zwi, Jonathan Hanning, Fritha Lim, Remy Williams, Andrew Cadwallader, Jon J Surg Case Rep Case Report Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder are rare. We present a case of a 72-year-old man who presented with back pain and acute renal failure. Ultrasound showed a soft tissue mass in the base of the bladder causing bilateral ureteric obstruction. Subsequent biopsy of this mass demonstrated neuroendocrine carcinoma. He was commenced on neoadjuvant chemotherapy (carboplatin/etoposide) and proceeded to a radical cysto-prostatectomy. Histology revealed a LCNEC involving the bladder, T4a with invasion through to adipose tissue and posteriorly at perivesical resection margins. In addition, there was a Gleason score 9 prostatic adenocarcinoma, distinct from the neuroendocrine carcinoma. Following surgery, the patient developed gross local-regional recurrence and refused further systemic therapy. However, 1 year following referral to palliative care, a further CT-PET showed complete spontaneous remission of his disease. There are only few case reports of LCNEC of the urinary bladder therefore the pathogenesis and treatment protocol are still unclear. This case report highlights the unpredictable nature of this disease. Oxford University Press 2017-05-11 /pmc/articles/PMC5441246/ /pubmed/28560016 http://dx.doi.org/10.1093/jscr/rjw179 Text en Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2017. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Chong, Vincent
Zwi, Jonathan
Hanning, Fritha
Lim, Remy
Williams, Andrew
Cadwallader, Jon
A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title_full A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title_fullStr A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title_full_unstemmed A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title_short A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
title_sort case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441246/
https://www.ncbi.nlm.nih.gov/pubmed/28560016
http://dx.doi.org/10.1093/jscr/rjw179
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