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Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread

Middle East respiratory syndrome coronavirus (MERS-CoV) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region. While the hypothesis that dromedary camels are the likely major source of MERS-CoV in...

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Autores principales: Crameri, Gary, Durr, Peter A., Barr, Jennifer, Yu, Meng, Graham, Kerryne, Williams, Owen J., Kayali, Ghazi, Smith, David, Peiris, Malik, Mackenzie, John S., Wang, Lin-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441328/
https://www.ncbi.nlm.nih.gov/pubmed/28616468
http://dx.doi.org/10.1016/j.onehlt.2015.10.003
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author Crameri, Gary
Durr, Peter A.
Barr, Jennifer
Yu, Meng
Graham, Kerryne
Williams, Owen J.
Kayali, Ghazi
Smith, David
Peiris, Malik
Mackenzie, John S.
Wang, Lin-Fa
author_facet Crameri, Gary
Durr, Peter A.
Barr, Jennifer
Yu, Meng
Graham, Kerryne
Williams, Owen J.
Kayali, Ghazi
Smith, David
Peiris, Malik
Mackenzie, John S.
Wang, Lin-Fa
author_sort Crameri, Gary
collection PubMed
description Middle East respiratory syndrome coronavirus (MERS-CoV) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region. While the hypothesis that dromedary camels are the likely major source of MERS-CoV infection in humans is gaining acceptance, conjecture continues over the original natural reservoir host(s) and specifically the role of bats in the emergence of the virus. Dromedary camels were imported to Australia, principally between 1880 and 1907 and have since become a large feral population inhabiting extensive parts of the continent. Here we report that during a focussed surveillance study, no serological evidence was found for the presence of MERS-CoV in the camels in the Australian population. This finding presents various hypotheses about the timing of the emergence and spread of MERS-CoV throughout populations of camels in Africa and Asia, which can be partially resolved by testing sera from camels from the original source region, which we have inferred was mainly northwestern Pakistan. In addition, we identify bat species which overlap (or neighbour) the range of the Australian camel population with a higher likelihood of carrying CoVs of the same lineage as MERS-CoV. Both of these proposed follow-on studies are examples of “proactive surveillance”, a concept that has particular relevance to a One Health approach to emerging zoonotic diseases with a complex epidemiology and aetiology.
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spelling pubmed-54413282017-06-14 Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread Crameri, Gary Durr, Peter A. Barr, Jennifer Yu, Meng Graham, Kerryne Williams, Owen J. Kayali, Ghazi Smith, David Peiris, Malik Mackenzie, John S. Wang, Lin-Fa One Health Research Paper Middle East respiratory syndrome coronavirus (MERS-CoV) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region. While the hypothesis that dromedary camels are the likely major source of MERS-CoV infection in humans is gaining acceptance, conjecture continues over the original natural reservoir host(s) and specifically the role of bats in the emergence of the virus. Dromedary camels were imported to Australia, principally between 1880 and 1907 and have since become a large feral population inhabiting extensive parts of the continent. Here we report that during a focussed surveillance study, no serological evidence was found for the presence of MERS-CoV in the camels in the Australian population. This finding presents various hypotheses about the timing of the emergence and spread of MERS-CoV throughout populations of camels in Africa and Asia, which can be partially resolved by testing sera from camels from the original source region, which we have inferred was mainly northwestern Pakistan. In addition, we identify bat species which overlap (or neighbour) the range of the Australian camel population with a higher likelihood of carrying CoVs of the same lineage as MERS-CoV. Both of these proposed follow-on studies are examples of “proactive surveillance”, a concept that has particular relevance to a One Health approach to emerging zoonotic diseases with a complex epidemiology and aetiology. Elsevier 2015-11-02 /pmc/articles/PMC5441328/ /pubmed/28616468 http://dx.doi.org/10.1016/j.onehlt.2015.10.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Crameri, Gary
Durr, Peter A.
Barr, Jennifer
Yu, Meng
Graham, Kerryne
Williams, Owen J.
Kayali, Ghazi
Smith, David
Peiris, Malik
Mackenzie, John S.
Wang, Lin-Fa
Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title_full Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title_fullStr Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title_full_unstemmed Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title_short Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread
title_sort absence of mers-cov antibodies in feral camels in australia: implications for the pathogen's origin and spread
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441328/
https://www.ncbi.nlm.nih.gov/pubmed/28616468
http://dx.doi.org/10.1016/j.onehlt.2015.10.003
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