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Predictive factors of uterine movement during definitive radiotherapy for cervical cancer

To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compa...

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Autores principales: Maemoto, Hitoshi, Toita, Takafumi, Ariga, Takuro, Heianna, Joichi, Yamashiro, Tsuneo, Murayama, Sadayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441382/
https://www.ncbi.nlm.nih.gov/pubmed/27744403
http://dx.doi.org/10.1093/jrr/rrw101
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author Maemoto, Hitoshi
Toita, Takafumi
Ariga, Takuro
Heianna, Joichi
Yamashiro, Tsuneo
Murayama, Sadayuki
author_facet Maemoto, Hitoshi
Toita, Takafumi
Ariga, Takuro
Heianna, Joichi
Yamashiro, Tsuneo
Murayama, Sadayuki
author_sort Maemoto, Hitoshi
collection PubMed
description To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT (n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction), 3.3 ± 2.9 mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical movement were smaller than those for the corpus. There was a significant, weak correlation between changes in bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significant difference in movement of the superior margin of the corpus between the subgroups with and without a history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the accurate prediction of uterine movement remains challenging.
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spelling pubmed-54413822017-05-30 Predictive factors of uterine movement during definitive radiotherapy for cervical cancer Maemoto, Hitoshi Toita, Takafumi Ariga, Takuro Heianna, Joichi Yamashiro, Tsuneo Murayama, Sadayuki J Radiat Res Oncology To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT (n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction), 3.3 ± 2.9 mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical movement were smaller than those for the corpus. There was a significant, weak correlation between changes in bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significant difference in movement of the superior margin of the corpus between the subgroups with and without a history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the accurate prediction of uterine movement remains challenging. Oxford University Press 2017-05 2016-10-15 /pmc/articles/PMC5441382/ /pubmed/27744403 http://dx.doi.org/10.1093/jrr/rrw101 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Oncology
Maemoto, Hitoshi
Toita, Takafumi
Ariga, Takuro
Heianna, Joichi
Yamashiro, Tsuneo
Murayama, Sadayuki
Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title_full Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title_fullStr Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title_full_unstemmed Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title_short Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
title_sort predictive factors of uterine movement during definitive radiotherapy for cervical cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441382/
https://www.ncbi.nlm.nih.gov/pubmed/27744403
http://dx.doi.org/10.1093/jrr/rrw101
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