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Predictive factors of uterine movement during definitive radiotherapy for cervical cancer
To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441382/ https://www.ncbi.nlm.nih.gov/pubmed/27744403 http://dx.doi.org/10.1093/jrr/rrw101 |
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author | Maemoto, Hitoshi Toita, Takafumi Ariga, Takuro Heianna, Joichi Yamashiro, Tsuneo Murayama, Sadayuki |
author_facet | Maemoto, Hitoshi Toita, Takafumi Ariga, Takuro Heianna, Joichi Yamashiro, Tsuneo Murayama, Sadayuki |
author_sort | Maemoto, Hitoshi |
collection | PubMed |
description | To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT (n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction), 3.3 ± 2.9 mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical movement were smaller than those for the corpus. There was a significant, weak correlation between changes in bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significant difference in movement of the superior margin of the corpus between the subgroups with and without a history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the accurate prediction of uterine movement remains challenging. |
format | Online Article Text |
id | pubmed-5441382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54413822017-05-30 Predictive factors of uterine movement during definitive radiotherapy for cervical cancer Maemoto, Hitoshi Toita, Takafumi Ariga, Takuro Heianna, Joichi Yamashiro, Tsuneo Murayama, Sadayuki J Radiat Res Oncology To determine the predictive factors affecting uterine movement during radiotherapy (RT), we quantified interfraction uterine movement using computed tomography (CT) and cone-beam CT (CBCT). A total of 38 patients who underwent definitive RT for cervical cancer were retrospectively analyzed. We compared pre-RT planning CT (n = 38) and intratreatment CBCT (n = 315), measuring cervical and corporal movement in each direction. Correlations between uterine movement and volume changes of the bladder and rectum on all CBCT scans were analyzed using Spearman rank correlation analysis. Relationships between the mean uterine movement and patient factors were analyzed using the Mann–Whitney test. The mean corpus movement was: superior margin (cranio–caudal direction), 7.6 ± 5.9 mm; anterior margin (anteroposterior direction), 8.3 ± 6.3 mm; left margin (lateral direction), 3.3 ± 2.9 mm; and right margin (lateral direction), 3.0 ± 2.3 mm. Generally, the mean values for cervical movement were smaller than those for the corpus. There was a significant, weak correlation between changes in bladder volume and the movement of the superior margin of the corpus (ρ = 0.364, P < 0.001). There was a significant difference in movement of the superior margin of the corpus between the subgroups with and without a history of previous pelvic surgery (P = 0.007). In conclusion, change in bladder volume and a history of previous surgery were significantly related to intrafractional corpus movement; however, our observations suggest that the accurate prediction of uterine movement remains challenging. Oxford University Press 2017-05 2016-10-15 /pmc/articles/PMC5441382/ /pubmed/27744403 http://dx.doi.org/10.1093/jrr/rrw101 Text en © The Author 2016. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Oncology Maemoto, Hitoshi Toita, Takafumi Ariga, Takuro Heianna, Joichi Yamashiro, Tsuneo Murayama, Sadayuki Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title | Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title_full | Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title_fullStr | Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title_full_unstemmed | Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title_short | Predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
title_sort | predictive factors of uterine movement during definitive radiotherapy for cervical cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441382/ https://www.ncbi.nlm.nih.gov/pubmed/27744403 http://dx.doi.org/10.1093/jrr/rrw101 |
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