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Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in v...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441392/ https://www.ncbi.nlm.nih.gov/pubmed/28588491 http://dx.doi.org/10.3389/fphar.2017.00289 |
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author | Gao, Jialiang Chen, Guang He, Haoqiang Liu, Chao Xiong, Xingjiang Li, Jun Wang, Jie |
author_facet | Gao, Jialiang Chen, Guang He, Haoqiang Liu, Chao Xiong, Xingjiang Li, Jun Wang, Jie |
author_sort | Gao, Jialiang |
collection | PubMed |
description | Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications. |
format | Online Article Text |
id | pubmed-5441392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54413922017-06-06 Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review Gao, Jialiang Chen, Guang He, Haoqiang Liu, Chao Xiong, Xingjiang Li, Jun Wang, Jie Front Pharmacol Pharmacology Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications. Frontiers Media S.A. 2017-05-23 /pmc/articles/PMC5441392/ /pubmed/28588491 http://dx.doi.org/10.3389/fphar.2017.00289 Text en Copyright © 2017 Gao, Chen, He, Liu, Xiong, Li and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Gao, Jialiang Chen, Guang He, Haoqiang Liu, Chao Xiong, Xingjiang Li, Jun Wang, Jie Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title_full | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title_fullStr | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title_full_unstemmed | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title_short | Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review |
title_sort | therapeutic effects of breviscapine in cardiovascular diseases: a review |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441392/ https://www.ncbi.nlm.nih.gov/pubmed/28588491 http://dx.doi.org/10.3389/fphar.2017.00289 |
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