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Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in v...

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Autores principales: Gao, Jialiang, Chen, Guang, He, Haoqiang, Liu, Chao, Xiong, Xingjiang, Li, Jun, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441392/
https://www.ncbi.nlm.nih.gov/pubmed/28588491
http://dx.doi.org/10.3389/fphar.2017.00289
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author Gao, Jialiang
Chen, Guang
He, Haoqiang
Liu, Chao
Xiong, Xingjiang
Li, Jun
Wang, Jie
author_facet Gao, Jialiang
Chen, Guang
He, Haoqiang
Liu, Chao
Xiong, Xingjiang
Li, Jun
Wang, Jie
author_sort Gao, Jialiang
collection PubMed
description Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications.
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spelling pubmed-54413922017-06-06 Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review Gao, Jialiang Chen, Guang He, Haoqiang Liu, Chao Xiong, Xingjiang Li, Jun Wang, Jie Front Pharmacol Pharmacology Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand.-Mazz., containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications. Frontiers Media S.A. 2017-05-23 /pmc/articles/PMC5441392/ /pubmed/28588491 http://dx.doi.org/10.3389/fphar.2017.00289 Text en Copyright © 2017 Gao, Chen, He, Liu, Xiong, Li and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gao, Jialiang
Chen, Guang
He, Haoqiang
Liu, Chao
Xiong, Xingjiang
Li, Jun
Wang, Jie
Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title_full Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title_fullStr Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title_full_unstemmed Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title_short Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review
title_sort therapeutic effects of breviscapine in cardiovascular diseases: a review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441392/
https://www.ncbi.nlm.nih.gov/pubmed/28588491
http://dx.doi.org/10.3389/fphar.2017.00289
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