GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

GPR40 (FFA1) is a fatty acid receptor whose activation results in potent glucose lowering and insulinotropic effects in vivo. Several reports illustrate that GPR40 agonists exert glucose lowering in diabetic humans. To assess the mechanisms by which GPR40 partial agonists improve glucose homeostasis...

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Detalles Bibliográficos
Autores principales: Miller, Corin, Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B., Li, Xiaoyan, Myers, Robert W., Knagge, Kevin, Carrington, Paul E., Hagmann, William K., Trujillo, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441580/
https://www.ncbi.nlm.nih.gov/pubmed/28542610
http://dx.doi.org/10.1371/journal.pone.0176182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441580/
https://www.ncbi.nlm.nih.gov/pubmed/28542610
http://dx.doi.org/10.1371/journal.pone.0176182

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