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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production
GPR40 (FFA1) is a fatty acid receptor whose activation results in potent glucose lowering and insulinotropic effects in vivo. Several reports illustrate that GPR40 agonists exert glucose lowering in diabetic humans. To assess the mechanisms by which GPR40 partial agonists improve glucose homeostasis...
Autores principales: | Miller, Corin, Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B., Li, Xiaoyan, Myers, Robert W., Knagge, Kevin, Carrington, Paul E., Hagmann, William K., Trujillo, Maria E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441580/ https://www.ncbi.nlm.nih.gov/pubmed/28542610 http://dx.doi.org/10.1371/journal.pone.0176182 |
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