Intracellular Ca(2+) homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis

BACKGROUND: Perioperative hypoxia may induce microglial inflammation and apoptosis, resulting in brain injury. The neuroprotective effect of propofol against hypoxia has been reported, but the underlying mechanisms are far from clear. In this study, we explored whether and how propofol could attenua...

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Detalles Bibliográficos
Autores principales: Lu, Yan, Gu, Yuechao, Ding, Xiaowei, Wang, Jiaqiang, Chen, Jiawei, Miao, Changhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441598/
https://www.ncbi.nlm.nih.gov/pubmed/28542400
http://dx.doi.org/10.1371/journal.pone.0178098

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