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mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy hom...

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Autores principales: Burke, Luke K, Darwish, Tamana, Cavanaugh, Althea R, Virtue, Sam, Roth, Emma, Morro, Joanna, Liu, Shun-Mei, Xia, Jing, Dalley, Jeffrey W, Burling, Keith, Chua, Streamson, Vidal-Puig, Toni, Schwartz, Gary J, Blouet, Clémence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441868/
https://www.ncbi.nlm.nih.gov/pubmed/28532548
http://dx.doi.org/10.7554/eLife.22848
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author Burke, Luke K
Darwish, Tamana
Cavanaugh, Althea R
Virtue, Sam
Roth, Emma
Morro, Joanna
Liu, Shun-Mei
Xia, Jing
Dalley, Jeffrey W
Burling, Keith
Chua, Streamson
Vidal-Puig, Toni
Schwartz, Gary J
Blouet, Clémence
author_facet Burke, Luke K
Darwish, Tamana
Cavanaugh, Althea R
Virtue, Sam
Roth, Emma
Morro, Joanna
Liu, Shun-Mei
Xia, Jing
Dalley, Jeffrey W
Burling, Keith
Chua, Streamson
Vidal-Puig, Toni
Schwartz, Gary J
Blouet, Clémence
author_sort Burke, Luke K
collection PubMed
description Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts. DOI: http://dx.doi.org/10.7554/eLife.22848.001
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spelling pubmed-54418682017-05-24 mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice Burke, Luke K Darwish, Tamana Cavanaugh, Althea R Virtue, Sam Roth, Emma Morro, Joanna Liu, Shun-Mei Xia, Jing Dalley, Jeffrey W Burling, Keith Chua, Streamson Vidal-Puig, Toni Schwartz, Gary J Blouet, Clémence eLife Human Biology and Medicine Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts. DOI: http://dx.doi.org/10.7554/eLife.22848.001 eLife Sciences Publications, Ltd 2017-05-23 /pmc/articles/PMC5441868/ /pubmed/28532548 http://dx.doi.org/10.7554/eLife.22848 Text en © 2017, Burke et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Burke, Luke K
Darwish, Tamana
Cavanaugh, Althea R
Virtue, Sam
Roth, Emma
Morro, Joanna
Liu, Shun-Mei
Xia, Jing
Dalley, Jeffrey W
Burling, Keith
Chua, Streamson
Vidal-Puig, Toni
Schwartz, Gary J
Blouet, Clémence
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title_full mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title_fullStr mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title_full_unstemmed mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title_short mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
title_sort mtorc1 in agrp neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441868/
https://www.ncbi.nlm.nih.gov/pubmed/28532548
http://dx.doi.org/10.7554/eLife.22848
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