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Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

Anaerobic thermophiles inhabit relic environments that resemble the early Earth. However, the lineage of these modern organisms co-evolved with our planet. Hence, these organisms carry both ancestral and acquired genes and serve as models to reconstruct early metabolism. Based on comparative genomic...

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Autores principales: Giovannelli, Donato, Sievert, Stefan M, Hügler, Michael, Markert, Stephanie, Becher, Dörte, Schweder, Thomas, Vetriani, Costantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441870/
https://www.ncbi.nlm.nih.gov/pubmed/28436819
http://dx.doi.org/10.7554/eLife.18990
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author Giovannelli, Donato
Sievert, Stefan M
Hügler, Michael
Markert, Stephanie
Becher, Dörte
Schweder, Thomas
Vetriani, Costantino
author_facet Giovannelli, Donato
Sievert, Stefan M
Hügler, Michael
Markert, Stephanie
Becher, Dörte
Schweder, Thomas
Vetriani, Costantino
author_sort Giovannelli, Donato
collection PubMed
description Anaerobic thermophiles inhabit relic environments that resemble the early Earth. However, the lineage of these modern organisms co-evolved with our planet. Hence, these organisms carry both ancestral and acquired genes and serve as models to reconstruct early metabolism. Based on comparative genomic and proteomic analyses, we identified two distinct groups of genes in Thermovibrio ammonificans: the first codes for enzymes that do not require oxygen and use substrates of geothermal origin; the second appears to be a more recent acquisition, and may reflect adaptations to cope with the rise of oxygen on Earth. We propose that the ancestor of the Aquificae was originally a hydrogen oxidizing, sulfur reducing bacterium that used a hybrid pathway for CO(2) fixation. With the gradual rise of oxygen in the atmosphere, more efficient terminal electron acceptors became available and this lineage acquired genes that increased its metabolic flexibility while retaining ancestral metabolic traits. DOI: http://dx.doi.org/10.7554/eLife.18990.001
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spelling pubmed-54418702017-05-24 Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans Giovannelli, Donato Sievert, Stefan M Hügler, Michael Markert, Stephanie Becher, Dörte Schweder, Thomas Vetriani, Costantino eLife Genomics and Evolutionary Biology Anaerobic thermophiles inhabit relic environments that resemble the early Earth. However, the lineage of these modern organisms co-evolved with our planet. Hence, these organisms carry both ancestral and acquired genes and serve as models to reconstruct early metabolism. Based on comparative genomic and proteomic analyses, we identified two distinct groups of genes in Thermovibrio ammonificans: the first codes for enzymes that do not require oxygen and use substrates of geothermal origin; the second appears to be a more recent acquisition, and may reflect adaptations to cope with the rise of oxygen on Earth. We propose that the ancestor of the Aquificae was originally a hydrogen oxidizing, sulfur reducing bacterium that used a hybrid pathway for CO(2) fixation. With the gradual rise of oxygen in the atmosphere, more efficient terminal electron acceptors became available and this lineage acquired genes that increased its metabolic flexibility while retaining ancestral metabolic traits. DOI: http://dx.doi.org/10.7554/eLife.18990.001 eLife Sciences Publications, Ltd 2017-04-24 /pmc/articles/PMC5441870/ /pubmed/28436819 http://dx.doi.org/10.7554/eLife.18990 Text en © 2017, Giovannelli et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Genomics and Evolutionary Biology
Giovannelli, Donato
Sievert, Stefan M
Hügler, Michael
Markert, Stephanie
Becher, Dörte
Schweder, Thomas
Vetriani, Costantino
Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title_full Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title_fullStr Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title_full_unstemmed Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title_short Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans
title_sort insight into the evolution of microbial metabolism from the deep-branching bacterium, thermovibrio ammonificans
topic Genomics and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441870/
https://www.ncbi.nlm.nih.gov/pubmed/28436819
http://dx.doi.org/10.7554/eLife.18990
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