Cargando…

Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)

Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the benefic...

Descripción completa

Detalles Bibliográficos
Autores principales: Lorenz, Mario, Rauhut, Franziska, Hofer, Christine, Gwosc, Stefanie, Müller, Eda, Praeger, Damaris, Zimmermann, Benno F., Wernecke, Klaus-Dieter, Baumann, Gert, Stangl, Karl, Stangl, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442103/
https://www.ncbi.nlm.nih.gov/pubmed/28536463
http://dx.doi.org/10.1038/s41598-017-02384-x
_version_ 1783238336794591232
author Lorenz, Mario
Rauhut, Franziska
Hofer, Christine
Gwosc, Stefanie
Müller, Eda
Praeger, Damaris
Zimmermann, Benno F.
Wernecke, Klaus-Dieter
Baumann, Gert
Stangl, Karl
Stangl, Verena
author_facet Lorenz, Mario
Rauhut, Franziska
Hofer, Christine
Gwosc, Stefanie
Müller, Eda
Praeger, Damaris
Zimmermann, Benno F.
Wernecke, Klaus-Dieter
Baumann, Gert
Stangl, Karl
Stangl, Verena
author_sort Lorenz, Mario
collection PubMed
description Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200 mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200 mg EGCG (p < 0.01). However, GTE and EGCG had no significant effect on FMD. NMD did not significantly differ between interventions. EGCG plasma levels were highest after administration of EGCG and lowest after consumption of green tea. Plasma levels of caffeine increased after green tea consumption. The results show that EGCG is most likely not involved in improvement of flow-mediated dilation by green tea. Instead, other tea compounds, metabolites or combinations thereof may play a role.
format Online
Article
Text
id pubmed-5442103
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-54421032017-05-25 Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG) Lorenz, Mario Rauhut, Franziska Hofer, Christine Gwosc, Stefanie Müller, Eda Praeger, Damaris Zimmermann, Benno F. Wernecke, Klaus-Dieter Baumann, Gert Stangl, Karl Stangl, Verena Sci Rep Article Consumption of tea is inversely associated with cardiovascular diseases. However, the active compound(s) responsible for the protective effects of tea are unknown. Although many favorable cardiovascular effects in vitro are mediated by epigallocatechin gallate (EGCG), its contribution to the beneficial effects of tea in vivo remains unresolved. In a randomised crossover study, a single dose of 200 mg EGCG was applied in three different formulas (as green tea beverage, green tea extract (GTE), and isolated EGCG) to 50 healthy men. Flow-mediated dilation (FMD) and endothelial-independent nitro-mediated dilation (NMD) was measured before and two hours after ingestion. Plasma levels of tea compounds were determined after each intervention and correlated with FMD. FMD significantly improved after consumption of green tea containing 200 mg EGCG (p < 0.01). However, GTE and EGCG had no significant effect on FMD. NMD did not significantly differ between interventions. EGCG plasma levels were highest after administration of EGCG and lowest after consumption of green tea. Plasma levels of caffeine increased after green tea consumption. The results show that EGCG is most likely not involved in improvement of flow-mediated dilation by green tea. Instead, other tea compounds, metabolites or combinations thereof may play a role. Nature Publishing Group UK 2017-05-23 /pmc/articles/PMC5442103/ /pubmed/28536463 http://dx.doi.org/10.1038/s41598-017-02384-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lorenz, Mario
Rauhut, Franziska
Hofer, Christine
Gwosc, Stefanie
Müller, Eda
Praeger, Damaris
Zimmermann, Benno F.
Wernecke, Klaus-Dieter
Baumann, Gert
Stangl, Karl
Stangl, Verena
Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_full Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_fullStr Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_full_unstemmed Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_short Tea-induced improvement of endothelial function in humans: No role for epigallocatechin gallate (EGCG)
title_sort tea-induced improvement of endothelial function in humans: no role for epigallocatechin gallate (egcg)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442103/
https://www.ncbi.nlm.nih.gov/pubmed/28536463
http://dx.doi.org/10.1038/s41598-017-02384-x
work_keys_str_mv AT lorenzmario teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT rauhutfranziska teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT hoferchristine teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT gwoscstefanie teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT mullereda teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT praegerdamaris teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT zimmermannbennof teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT werneckeklausdieter teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT baumanngert teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT stanglkarl teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg
AT stanglverena teainducedimprovementofendothelialfunctioninhumansnoroleforepigallocatechingallateegcg