Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC has to escape the host’s immuno-surveillance, e.g. by loss of HLA class-I expression. Indeed, a reduced HLA class-I expr...

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Detalles Bibliográficos
Autores principales: Ritter, Cathrin, Fan, Kaiji, Paschen, Annette, Reker Hardrup, Sine, Ferrone, Soldano, Nghiem, Paul, Ugurel, Selma, Schrama, David, Becker, Jürgen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442125/
https://www.ncbi.nlm.nih.gov/pubmed/28536458
http://dx.doi.org/10.1038/s41598-017-02608-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442125/
https://www.ncbi.nlm.nih.gov/pubmed/28536458
http://dx.doi.org/10.1038/s41598-017-02608-0

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