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Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil

Drug-tolerant cancer cell subpopulations are responsible for relapse after chemotherapy. By continuously exposing the gastric cancer cell line MKN45 to 5-FU for >100 passages, we established a 5-fluorouracil (5-FU)-tolerant line, MKN45/5FU. Orthotopic xenografts of MKN45/5FU cells in the stomach...

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Detalles Bibliográficos
Autores principales:	Ishida, Kaoru, Ito, Chie, Ohmori, Yukimi, Kume, Kohei, Sato, Kei A., Koizumi, Yuka, Konta, Akari, Iwaya, Takeshi, Nukatsuka, Mamoru, Kobunai, Takashi, Takechi, Teiji, Nishizuka, Satoshi S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442158/ https://www.ncbi.nlm.nih.gov/pubmed/28536445 http://dx.doi.org/10.1038/s41598-017-02548-9

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