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Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression
Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442179/ https://www.ncbi.nlm.nih.gov/pubmed/28596724 http://dx.doi.org/10.3389/fncel.2017.00150 |
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author | McIntosh, Allison L. Gormley, Shane Tozzi, Leonardo Frodl, Thomas Harkin, Andrew |
author_facet | McIntosh, Allison L. Gormley, Shane Tozzi, Leonardo Frodl, Thomas Harkin, Andrew |
author_sort | McIntosh, Allison L. |
collection | PubMed |
description | Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes. Recent advances in preclinical imaging have facilitated significant developments within the field, particularly relating to high resolution structural imaging and resting-state functional imaging which are emerging techniques in clinical research. This review aims to bring together the current literature on preclinical neuroimaging in animal models of stress and depression, highlighting promising avenues of research toward understanding the pathological basis of this hugely prevalent disorder. |
format | Online Article Text |
id | pubmed-5442179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54421792017-06-08 Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression McIntosh, Allison L. Gormley, Shane Tozzi, Leonardo Frodl, Thomas Harkin, Andrew Front Cell Neurosci Neuroscience Magnetic resonance imaging (MRI) is a valuable translational tool that can be used to investigate alterations in brain structure and function in both patients and animal models of disease. Regional changes in brain structure, functional connectivity, and metabolite concentrations have been reported in depressed patients, giving insight into the networks and brain regions involved, however preclinical models are less well characterized. The development of more effective treatments depends upon animal models that best translate to the human condition and animal models may be exploited to assess the molecular and cellular alterations that accompany neuroimaging changes. Recent advances in preclinical imaging have facilitated significant developments within the field, particularly relating to high resolution structural imaging and resting-state functional imaging which are emerging techniques in clinical research. This review aims to bring together the current literature on preclinical neuroimaging in animal models of stress and depression, highlighting promising avenues of research toward understanding the pathological basis of this hugely prevalent disorder. Frontiers Media S.A. 2017-05-24 /pmc/articles/PMC5442179/ /pubmed/28596724 http://dx.doi.org/10.3389/fncel.2017.00150 Text en Copyright © 2017 McIntosh, Gormley, Tozzi, Frodl and Harkin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience McIntosh, Allison L. Gormley, Shane Tozzi, Leonardo Frodl, Thomas Harkin, Andrew Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title | Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title_full | Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title_fullStr | Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title_full_unstemmed | Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title_short | Recent Advances in Translational Magnetic Resonance Imaging in Animal Models of Stress and Depression |
title_sort | recent advances in translational magnetic resonance imaging in animal models of stress and depression |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442179/ https://www.ncbi.nlm.nih.gov/pubmed/28596724 http://dx.doi.org/10.3389/fncel.2017.00150 |
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