Cargando…

African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?

African trypanosomosis is a debilitating disease of great medical and socioeconomical importance. It is caused by strictly extracellular protozoan parasites capable of infecting all vertebrate classes including human, livestock, and game animals. To survive within their mammalian host, trypanosomes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stijlemans, Benoit, Radwanska, Magdalena, De Trez, Carl, Magez, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442186/ https://www.ncbi.nlm.nih.gov/pubmed/28596768 http://dx.doi.org/10.3389/fimmu.2017.00582

Ejemplares similares

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm
por: Stijlemans, Benoit, et al.
Publicado: (2022)

Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections
por: Nguyen, Hang Thi Thu, et al.
Publicado: (2022)

Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System
por: Magez, Stefan, et al.
Publicado: (2020)

African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System
por: Stijlemans, Benoit, et al.
Publicado: (2018)

Trypanosomiasis-Induced B Cell Apoptosis Results in Loss of Protective Anti-Parasite Antibody Responses and Abolishment of Vaccine-Induced Memory Responses
por: Radwanska, Magdalena, et al.
Publicado: (2008)

The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review
por: Kariuki, Christopher K., et al.
Publicado: (2019)

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity
por: Stijlemans, Benoît, et al.
Publicado: (2016)

Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells
por: De Beule, Nathan, et al.
Publicado: (2017)

Correction: Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells
por: De Beule, Nathan, et al.
Publicado: (2018)

Experimental African Trypanosome Infection by Needle Passage or Natural Tsetse Fly Challenge Thwarts the Development of Collagen-Induced Arthritis in DBA/1 Prone Mice via an Impairment of Antigen Specific B Cell Autoantibody Titers
por: De Trez, Carl, et al.
Publicado: (2015)

A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection
por: De Trez, Carl, et al.
Publicado: (2020)

Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis
por: Stijlemans, Benoit, et al.
Publicado: (2017)

African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory So That Post-Treatment Bordetella pertussis Challenge Fails to Trigger a Protective Recall Response
por: Radwanska, Magdalena, et al.
Publicado: (2021)

Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes
por: Obishakin, Emmanuel, et al.
Publicado: (2014)

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System
por: Magez, Stefan, et al.
Publicado: (2021)

Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System
por: Radwanska, Magdalena, et al.
Publicado: (2018)

To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host
por: Alfituri, Omar A., et al.
Publicado: (2020)

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection
por: Stijlemans, Benoit, et al.
Publicado: (2020)

T. brucei infections abrogate diverse plasma cell-mediated effector B cell responses, independently of their specificity, affinity and host genetic background
por: De Trez, Carl, et al.
Publicado: (2020)

Corrigendum: To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host
por: Alfituri, Omar A., et al.
Publicado: (2021)

Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice
por: Deleeuw, Violette, et al.
Publicado: (2019)

The Humoral Immune Response to BCG Vaccination
por: Tanner, Rachel, et al.
Publicado: (2019)

Interferon Gamma in African Trypanosome Infections: Friends or Foes?
por: Wu, Hui, et al.
Publicado: (2017)

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia
por: Cnops, Jennifer, et al.
Publicado: (2015)

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030
por: Álvarez-Rodríguez, Andrés, et al.
Publicado: (2022)

Vaccination against trypanosomiasis: Can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?
por: La Greca, Florencia, et al.
Publicado: (2011)

The History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples
por: Magez, Stefan, et al.
Publicado: (2021)

STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major
por: Kauffmann, Florence, et al.
Publicado: (2018)

The Humoral Immune Response to HCV: Understanding is Key to Vaccine Development
por: Cashman, Siobhán B., et al.
Publicado: (2014)

Humoral and cellular immunogenicity of COVID-19 booster dose vaccination in inflammatory arthritis patients
por: Wroński, Jakub, et al.
Publicado: (2022)

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis
por: Stijlemans, Benoît, et al.
Publicado: (2011)

African trypanosomes
por: Cayla, Mathieu, et al.
Publicado: (2019)

The DNA damage response is developmentally regulated in the African trypanosome
por: Vieira-da-Rocha, J.P., et al.
Publicado: (2019)

DNA Vaccines Against Mycoplasma Elicit Humoral Immune Responses in Ostriches
por: Wium, Martha, et al.
Publicado: (2019)

In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response
por: Baniel, Claire C., et al.
Publicado: (2020)

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis
por: Stijlemans, Benoît, et al.
Publicado: (2016)

Humoral Immune Response to AAV
por: Calcedo, Roberto, et al.
Publicado: (2013)

Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine
por: Cait, Alissa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_npigc2i9chmcq32kbbs3m3tocl