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RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model

Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response....

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Autores principales: Sojod, Bouchra, Chateau, Danielle, Mueller, Christopher G., Babajko, Sylvie, Berdal, Ariane, Lézot, Frédéric, Castaneda, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442248/
https://www.ncbi.nlm.nih.gov/pubmed/28596739
http://dx.doi.org/10.3389/fphys.2017.00338
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author Sojod, Bouchra
Chateau, Danielle
Mueller, Christopher G.
Babajko, Sylvie
Berdal, Ariane
Lézot, Frédéric
Castaneda, Beatriz
author_facet Sojod, Bouchra
Chateau, Danielle
Mueller, Christopher G.
Babajko, Sylvie
Berdal, Ariane
Lézot, Frédéric
Castaneda, Beatriz
author_sort Sojod, Bouchra
collection PubMed
description Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (R(Tg)) and develops a periodontitis-like phenotype at 5 months of age. R(Tg) mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of periodontal ligaments. This phenotype was more pronounced in females. We also observed dental root resorption lacunas. Hyperplasia of the gingival epithelium, including Malassez epithelial rests, was visible as early as 25 days, preceding any other symptoms. These results demonstrate that perturbations of the RANKL/RANK/OPG system constitute a core element of periodontitis, and more globally, osteo-immune diseases.
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spelling pubmed-54422482017-06-08 RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model Sojod, Bouchra Chateau, Danielle Mueller, Christopher G. Babajko, Sylvie Berdal, Ariane Lézot, Frédéric Castaneda, Beatriz Front Physiol Physiology Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (R(Tg)) and develops a periodontitis-like phenotype at 5 months of age. R(Tg) mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of periodontal ligaments. This phenotype was more pronounced in females. We also observed dental root resorption lacunas. Hyperplasia of the gingival epithelium, including Malassez epithelial rests, was visible as early as 25 days, preceding any other symptoms. These results demonstrate that perturbations of the RANKL/RANK/OPG system constitute a core element of periodontitis, and more globally, osteo-immune diseases. Frontiers Media S.A. 2017-05-24 /pmc/articles/PMC5442248/ /pubmed/28596739 http://dx.doi.org/10.3389/fphys.2017.00338 Text en Copyright © 2017 Sojod, Chateau, Mueller, Babajko, Berdal, Lézot and Castaneda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Sojod, Bouchra
Chateau, Danielle
Mueller, Christopher G.
Babajko, Sylvie
Berdal, Ariane
Lézot, Frédéric
Castaneda, Beatriz
RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title_full RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title_fullStr RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title_full_unstemmed RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title_short RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
title_sort rank/rankl/opg signalization implication in periodontitis: new evidence from a rank transgenic mouse model
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442248/
https://www.ncbi.nlm.nih.gov/pubmed/28596739
http://dx.doi.org/10.3389/fphys.2017.00338
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