Cargando…
RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model
Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response....
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442248/ https://www.ncbi.nlm.nih.gov/pubmed/28596739 http://dx.doi.org/10.3389/fphys.2017.00338 |
_version_ | 1783238369024671744 |
---|---|
author | Sojod, Bouchra Chateau, Danielle Mueller, Christopher G. Babajko, Sylvie Berdal, Ariane Lézot, Frédéric Castaneda, Beatriz |
author_facet | Sojod, Bouchra Chateau, Danielle Mueller, Christopher G. Babajko, Sylvie Berdal, Ariane Lézot, Frédéric Castaneda, Beatriz |
author_sort | Sojod, Bouchra |
collection | PubMed |
description | Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (R(Tg)) and develops a periodontitis-like phenotype at 5 months of age. R(Tg) mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of periodontal ligaments. This phenotype was more pronounced in females. We also observed dental root resorption lacunas. Hyperplasia of the gingival epithelium, including Malassez epithelial rests, was visible as early as 25 days, preceding any other symptoms. These results demonstrate that perturbations of the RANKL/RANK/OPG system constitute a core element of periodontitis, and more globally, osteo-immune diseases. |
format | Online Article Text |
id | pubmed-5442248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54422482017-06-08 RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model Sojod, Bouchra Chateau, Danielle Mueller, Christopher G. Babajko, Sylvie Berdal, Ariane Lézot, Frédéric Castaneda, Beatriz Front Physiol Physiology Periodontitis is based on a complex inflammatory over-response combined with possible genetic predisposition factors. The RANKL/RANK/OPG signaling pathway is implicated in bone resorption through its key function in osteoclast differentiation and activation, as well as in the inflammatory response. This central element of osteo-immunology has been suggested to be perturbed in several diseases, including periodontitis, as it is a predisposing factor for this disease. The aim of the present study was to validate this hypothesis using a transgenic mouse line, which over-expresses RANK (R(Tg)) and develops a periodontitis-like phenotype at 5 months of age. R(Tg) mice exhibited severe alveolar bone loss, an increased number of TRAP positive cells, and disorganization of periodontal ligaments. This phenotype was more pronounced in females. We also observed dental root resorption lacunas. Hyperplasia of the gingival epithelium, including Malassez epithelial rests, was visible as early as 25 days, preceding any other symptoms. These results demonstrate that perturbations of the RANKL/RANK/OPG system constitute a core element of periodontitis, and more globally, osteo-immune diseases. Frontiers Media S.A. 2017-05-24 /pmc/articles/PMC5442248/ /pubmed/28596739 http://dx.doi.org/10.3389/fphys.2017.00338 Text en Copyright © 2017 Sojod, Chateau, Mueller, Babajko, Berdal, Lézot and Castaneda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Sojod, Bouchra Chateau, Danielle Mueller, Christopher G. Babajko, Sylvie Berdal, Ariane Lézot, Frédéric Castaneda, Beatriz RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title | RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title_full | RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title_fullStr | RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title_full_unstemmed | RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title_short | RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model |
title_sort | rank/rankl/opg signalization implication in periodontitis: new evidence from a rank transgenic mouse model |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442248/ https://www.ncbi.nlm.nih.gov/pubmed/28596739 http://dx.doi.org/10.3389/fphys.2017.00338 |
work_keys_str_mv | AT sojodbouchra rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT chateaudanielle rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT muellerchristopherg rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT babajkosylvie rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT berdalariane rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT lezotfrederic rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel AT castanedabeatriz rankranklopgsignalizationimplicationinperiodontitisnewevidencefromaranktransgenicmousemodel |