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Application of Fuzzy Logic in Oral Cancer Risk Assessment
BACKGROUND: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. METHODS: Se...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442273/ https://www.ncbi.nlm.nih.gov/pubmed/28560191 |
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author | SCROBOTĂ, Ioana BĂCIUȚ, Grigore FILIP, Adriana Gabriela TODOR, Bianca BLAGA, Florin BĂCIUȚ, Mihaela Felicia |
author_facet | SCROBOTĂ, Ioana BĂCIUȚ, Grigore FILIP, Adriana Gabriela TODOR, Bianca BLAGA, Florin BĂCIUȚ, Mihaela Felicia |
author_sort | SCROBOTĂ, Ioana |
collection | PubMed |
description | BACKGROUND: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. METHODS: Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012–2014). RESULTS: We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors’ values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. CONCLUSION: The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders. |
format | Online Article Text |
id | pubmed-5442273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-54422732017-05-30 Application of Fuzzy Logic in Oral Cancer Risk Assessment SCROBOTĂ, Ioana BĂCIUȚ, Grigore FILIP, Adriana Gabriela TODOR, Bianca BLAGA, Florin BĂCIUȚ, Mihaela Felicia Iran J Public Health Original Article BACKGROUND: The mapping of the malignization mechanism is still incomplete, but oxidative stress is strongly correlated to carcinogenesis. In our research, using fuzzy logic, we aimed to estimate the oxidative stress related-cancerization risk of the oral potentially malignant disorders. METHODS: Serum from 16 patients diagnosed (clinical and histopathological) with oral potentially malignant disorders (Dept. of Cranio-Maxillofacial Surgery and Radiology, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania) was processed fluorometric for malondialdehyde and proton donors assays (Dept. of Physiology,”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania). The values were used as inputs, they were associated linguistic terms using MIN-MAX method and 25 IF-THEN inference rules were generated to estimate the output value, the cancerization risk appreciated on a scale from 1 to 10 - IF malondialdehyde is very high and donors protons are very low THEN the cancer risk is reaching the maximum value (Dept. of Industrial Engineering, Faculty of Managerial and Technological Engineering, University of Oradea, Oradea, Romania) (2012–2014). RESULTS: We estimated the cancerization risk of the oral potentially malignant disorders by implementing the multi-criteria decision support system based on serum malondialdehyde and proton donors’ values. The risk was estimated as a concrete numerical value on a scale from 1 to 10 depending on the input numerical/linguistic value. CONCLUSION: The multi-criteria decision support system proposed by us, integrated into a more complex computerized decision support system, could be used as an important aid in oral cancer screening and establish future medical decision in oral potentially malignant disorders. Tehran University of Medical Sciences 2017-05 /pmc/articles/PMC5442273/ /pubmed/28560191 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article SCROBOTĂ, Ioana BĂCIUȚ, Grigore FILIP, Adriana Gabriela TODOR, Bianca BLAGA, Florin BĂCIUȚ, Mihaela Felicia Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title | Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title_full | Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title_fullStr | Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title_full_unstemmed | Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title_short | Application of Fuzzy Logic in Oral Cancer Risk Assessment |
title_sort | application of fuzzy logic in oral cancer risk assessment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442273/ https://www.ncbi.nlm.nih.gov/pubmed/28560191 |
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