YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate...

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Detalles Bibliográficos
Autores principales: Totaro, Antonio, Castellan, Martina, Battilana, Giusy, Zanconato, Francesca, Azzolin, Luca, Giulitti, Stefano, Cordenonsi, Michelangelo, Piccolo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442321/
https://www.ncbi.nlm.nih.gov/pubmed/28513598
http://dx.doi.org/10.1038/ncomms15206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442321/
https://www.ncbi.nlm.nih.gov/pubmed/28513598
http://dx.doi.org/10.1038/ncomms15206

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