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An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data

Here we present HiC-DC, a principled method to estimate the statistical significance (P values) of chromatin interactions from Hi-C experiments. HiC-DC uses hurdle negative binomial regression account for systematic sources of variation in Hi-C read counts—for example, distance-dependent random poly...

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Detalles Bibliográficos
Autores principales:	Carty, Mark, Zamparo, Lee, Sahin, Merve, González, Alvaro, Pelossof, Raphael, Elemento, Olivier, Leslie, Christina S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442359/ https://www.ncbi.nlm.nih.gov/pubmed/28513628 http://dx.doi.org/10.1038/ncomms15454

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