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Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoa...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Les Laboratoires Servier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442365/ https://www.ncbi.nlm.nih.gov/pubmed/28566948 |
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author | Gréa, Hélène Scheid, Isabelle Gaman, Alexandru Rogemond, Véronique Gillet, Sandy Honnorat, Jérôme Bolognani, Federico Czech, Christian Bouquet, Céline Toledano, Elie Bouvard, Manuel Delorme, Richard Groc, Laurent Leboyer, Marion |
author_facet | Gréa, Hélène Scheid, Isabelle Gaman, Alexandru Rogemond, Véronique Gillet, Sandy Honnorat, Jérôme Bolognani, Federico Czech, Christian Bouquet, Céline Toledano, Elie Bouvard, Manuel Delorme, Richard Groc, Laurent Leboyer, Marion |
author_sort | Gréa, Hélène |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab). The patient exhibited alexithymia and previously suffered from two major depressive episodes without psychotic symptoms. Using a single molecule-based imaging approach, we demonstrate that neither NMDAR-Ab type G immunoglobulin purified from the ASD patient serum, nor that from a seropositive healthy subject, disorganize membrane NMDAR complexes at synapses. These findings suggest that the autistic patient NMDAR-Abs do not play a direct role in the etiology of ASD and that other autoantibodies directed against neuronal targets should be investigated. |
format | Online Article Text |
id | pubmed-5442365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54423652017-05-31 Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody Gréa, Hélène Scheid, Isabelle Gaman, Alexandru Rogemond, Véronique Gillet, Sandy Honnorat, Jérôme Bolognani, Federico Czech, Christian Bouquet, Céline Toledano, Elie Bouvard, Manuel Delorme, Richard Groc, Laurent Leboyer, Marion Dialogues Clin Neurosci Brief Report Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab). The patient exhibited alexithymia and previously suffered from two major depressive episodes without psychotic symptoms. Using a single molecule-based imaging approach, we demonstrate that neither NMDAR-Ab type G immunoglobulin purified from the ASD patient serum, nor that from a seropositive healthy subject, disorganize membrane NMDAR complexes at synapses. These findings suggest that the autistic patient NMDAR-Abs do not play a direct role in the etiology of ASD and that other autoantibodies directed against neuronal targets should be investigated. Les Laboratoires Servier 2017-03 /pmc/articles/PMC5442365/ /pubmed/28566948 Text en Copyright ©2017 AICH - Servier Research Group. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Gréa, Hélène Scheid, Isabelle Gaman, Alexandru Rogemond, Véronique Gillet, Sandy Honnorat, Jérôme Bolognani, Federico Czech, Christian Bouquet, Céline Toledano, Elie Bouvard, Manuel Delorme, Richard Groc, Laurent Leboyer, Marion Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title | Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title_full | Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title_fullStr | Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title_full_unstemmed | Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title_short | Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody |
title_sort | clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—nmda-receptor autoantibody |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442365/ https://www.ncbi.nlm.nih.gov/pubmed/28566948 |
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