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Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoa...

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Autores principales: Gréa, Hélène, Scheid, Isabelle, Gaman, Alexandru, Rogemond, Véronique, Gillet, Sandy, Honnorat, Jérôme, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Toledano, Elie, Bouvard, Manuel, Delorme, Richard, Groc, Laurent, Leboyer, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442365/
https://www.ncbi.nlm.nih.gov/pubmed/28566948
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author Gréa, Hélène
Scheid, Isabelle
Gaman, Alexandru
Rogemond, Véronique
Gillet, Sandy
Honnorat, Jérôme
Bolognani, Federico
Czech, Christian
Bouquet, Céline
Toledano, Elie
Bouvard, Manuel
Delorme, Richard
Groc, Laurent
Leboyer, Marion
author_facet Gréa, Hélène
Scheid, Isabelle
Gaman, Alexandru
Rogemond, Véronique
Gillet, Sandy
Honnorat, Jérôme
Bolognani, Federico
Czech, Christian
Bouquet, Céline
Toledano, Elie
Bouvard, Manuel
Delorme, Richard
Groc, Laurent
Leboyer, Marion
author_sort Gréa, Hélène
collection PubMed
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab). The patient exhibited alexithymia and previously suffered from two major depressive episodes without psychotic symptoms. Using a single molecule-based imaging approach, we demonstrate that neither NMDAR-Ab type G immunoglobulin purified from the ASD patient serum, nor that from a seropositive healthy subject, disorganize membrane NMDAR complexes at synapses. These findings suggest that the autistic patient NMDAR-Abs do not play a direct role in the etiology of ASD and that other autoantibodies directed against neuronal targets should be investigated.
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spelling pubmed-54423652017-05-31 Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody Gréa, Hélène Scheid, Isabelle Gaman, Alexandru Rogemond, Véronique Gillet, Sandy Honnorat, Jérôme Bolognani, Federico Czech, Christian Bouquet, Céline Toledano, Elie Bouvard, Manuel Delorme, Richard Groc, Laurent Leboyer, Marion Dialogues Clin Neurosci Brief Report Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab). The patient exhibited alexithymia and previously suffered from two major depressive episodes without psychotic symptoms. Using a single molecule-based imaging approach, we demonstrate that neither NMDAR-Ab type G immunoglobulin purified from the ASD patient serum, nor that from a seropositive healthy subject, disorganize membrane NMDAR complexes at synapses. These findings suggest that the autistic patient NMDAR-Abs do not play a direct role in the etiology of ASD and that other autoantibodies directed against neuronal targets should be investigated. Les Laboratoires Servier 2017-03 /pmc/articles/PMC5442365/ /pubmed/28566948 Text en Copyright ©2017 AICH - Servier Research Group. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Gréa, Hélène
Scheid, Isabelle
Gaman, Alexandru
Rogemond, Véronique
Gillet, Sandy
Honnorat, Jérôme
Bolognani, Federico
Czech, Christian
Bouquet, Céline
Toledano, Elie
Bouvard, Manuel
Delorme, Richard
Groc, Laurent
Leboyer, Marion
Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title_full Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title_fullStr Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title_full_unstemmed Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title_short Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
title_sort clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—nmda-receptor autoantibody
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442365/
https://www.ncbi.nlm.nih.gov/pubmed/28566948
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