DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer

The gene encoding ‘deleted in breast cancer 2' (DBC2), also referred to as RHOBTB2 (Rho-related BTB domain-containing protein 2), is classified as a tumor suppressor gene. DBC2 is a substrate-specific adaptor protein for a novel class of Cullin-3 (CUL3)-based E3 ubiquitin ligases; however, it i...

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Detalles Bibliográficos
Autores principales: Choi, Y M, Kim, K B, Lee, J H, Chun, Y K, An, I S, An, S, Bae, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442418/
https://www.ncbi.nlm.nih.gov/pubmed/27941885
http://dx.doi.org/10.1038/onc.2016.441

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