Cancer heterogeneity is not compatible with one unique cancer cell metabolic map

The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are presented in textbooks and reviews as a hallmark (general characteristic): the metabolic map of cancer. On the other hand, research articles on specific tumors since a few years emphasize various biological fe...

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Autores principales: Strickaert, A, Saiselet, M, Dom, G, De Deken, X, Dumont, J E, Feron, O, Sonveaux, P, Maenhaut, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442421/
https://www.ncbi.nlm.nih.gov/pubmed/27797377
http://dx.doi.org/10.1038/onc.2016.411
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author Strickaert, A
Saiselet, M
Dom, G
De Deken, X
Dumont, J E
Feron, O
Sonveaux, P
Maenhaut, C
author_facet Strickaert, A
Saiselet, M
Dom, G
De Deken, X
Dumont, J E
Feron, O
Sonveaux, P
Maenhaut, C
author_sort Strickaert, A
collection PubMed
description The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are presented in textbooks and reviews as a hallmark (general characteristic): the metabolic map of cancer. On the other hand, research articles on specific tumors since a few years emphasize various biological features of different cancers, different cells in a cancer and the dynamic heterogeneity of these cells. We have analysed the research literature of the subject and show the generality of a dynamic, evolving biological and metabolic, spatial and temporal heterogeneity of individual cancers. We conclude that there is no one metabolic map of cancer but several and describe the two extremes of a panel from the hypoxic to the normoxic state. The implications for the significance of general ‘omic' studies, and on therapeutic conclusions drawn from them and for the diagnostic use of fractional biopsies is discussed.
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spelling pubmed-54424212017-06-02 Cancer heterogeneity is not compatible with one unique cancer cell metabolic map Strickaert, A Saiselet, M Dom, G De Deken, X Dumont, J E Feron, O Sonveaux, P Maenhaut, C Oncogene Review The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are presented in textbooks and reviews as a hallmark (general characteristic): the metabolic map of cancer. On the other hand, research articles on specific tumors since a few years emphasize various biological features of different cancers, different cells in a cancer and the dynamic heterogeneity of these cells. We have analysed the research literature of the subject and show the generality of a dynamic, evolving biological and metabolic, spatial and temporal heterogeneity of individual cancers. We conclude that there is no one metabolic map of cancer but several and describe the two extremes of a panel from the hypoxic to the normoxic state. The implications for the significance of general ‘omic' studies, and on therapeutic conclusions drawn from them and for the diagnostic use of fractional biopsies is discussed. Nature Publishing Group 2017-05-11 2016-10-31 /pmc/articles/PMC5442421/ /pubmed/27797377 http://dx.doi.org/10.1038/onc.2016.411 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Strickaert, A
Saiselet, M
Dom, G
De Deken, X
Dumont, J E
Feron, O
Sonveaux, P
Maenhaut, C
Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title_full Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title_fullStr Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title_full_unstemmed Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title_short Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
title_sort cancer heterogeneity is not compatible with one unique cancer cell metabolic map
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442421/
https://www.ncbi.nlm.nih.gov/pubmed/27797377
http://dx.doi.org/10.1038/onc.2016.411
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