TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability

Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. TGF-β signals via Smad and non-Smad pathways. Under normal conditions, wild-type p53 forms a complex with Smad2/3 and co-activates transcription of a variety of tumor suppressor gen...

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Detalles Bibliográficos
Autores principales: Liu, W-T, Huang, K-Y, Lu, M-C, Huang, H-L, Chen, C-Y, Cheng, Y-L, Yu, H-C, Liu, S-Q, Lai, N-S, Huang, H-B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442427/
https://www.ncbi.nlm.nih.gov/pubmed/27893708
http://dx.doi.org/10.1038/onc.2016.424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442427/
https://www.ncbi.nlm.nih.gov/pubmed/27893708
http://dx.doi.org/10.1038/onc.2016.424

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