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Chloroquine inhibits Ca(2+) permeable ion channels-mediated Ca(2+) signaling in primary B lymphocytes

BACKGROUND: Chloroquine, a bitter tastant, inhibits Ca(2+) signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear. RESULTS: In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca(2+) increases in mouse splenic prima...

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Detalles Bibliográficos
Autores principales:	Wu, Yi-Fan, Zhao, Ping, Luo, Xi, Xu, Jin-Chao, Xue, Lu, Zhou, Qi, Xiong, Mingrui, Shen, Jinhua, Peng, Yong-Bo, Yu, Meng-Fei, Chen, Weiwei, Ma, Liqun, Liu, Qing-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442594/ https://www.ncbi.nlm.nih.gov/pubmed/28546857 http://dx.doi.org/10.1186/s13578-017-0155-5

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