Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions

[Image: see text] Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting mater...

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Autores principales: Tona, Veronica, Maryasin, Boris, de la Torre, Aurélien, Sprachmann, Josefine, González, Leticia, Maulide, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442602/
https://www.ncbi.nlm.nih.gov/pubmed/28485608
http://dx.doi.org/10.1021/acs.orglett.7b01004
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author Tona, Veronica
Maryasin, Boris
de la Torre, Aurélien
Sprachmann, Josefine
González, Leticia
Maulide, Nuno
author_facet Tona, Veronica
Maryasin, Boris
de la Torre, Aurélien
Sprachmann, Josefine
González, Leticia
Maulide, Nuno
author_sort Tona, Veronica
collection PubMed
description [Image: see text] Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.
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spelling pubmed-54426022017-05-26 Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions Tona, Veronica Maryasin, Boris de la Torre, Aurélien Sprachmann, Josefine González, Leticia Maulide, Nuno Org Lett [Image: see text] Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance. American Chemical Society 2017-05-09 2017-05-19 /pmc/articles/PMC5442602/ /pubmed/28485608 http://dx.doi.org/10.1021/acs.orglett.7b01004 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Tona, Veronica
Maryasin, Boris
de la Torre, Aurélien
Sprachmann, Josefine
González, Leticia
Maulide, Nuno
Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title_full Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title_fullStr Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title_full_unstemmed Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title_short Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions
title_sort direct regioselective synthesis of tetrazolium salts by activation of secondary amides under mild conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442602/
https://www.ncbi.nlm.nih.gov/pubmed/28485608
http://dx.doi.org/10.1021/acs.orglett.7b01004
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