Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Previous studies have indicated that the G-protein-coupled secretin receptor is present as a homodimer, organized through symmetrical contacts in transmembrane domain IV, and that receptor dimerization is critical for high-potency signalling by secretin. However, whether all of the receptor exists i...

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Detalles Bibliográficos
Autores principales: Ward, Richard J., Pediani, John D., Harikumar, Kaleeckal G., Miller, Laurence J., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442643/
https://www.ncbi.nlm.nih.gov/pubmed/28424368
http://dx.doi.org/10.1042/BCJ20170184

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