Cargando…

The spleen in liver cirrhosis: revisiting an old enemy with novel targets

The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Liang, Duan, Mubing, Chen, Weisan, Jiang, An, Li, Xiaoming, Yang, Jun, Li, Zongfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442653/
https://www.ncbi.nlm.nih.gov/pubmed/28535799
http://dx.doi.org/10.1186/s12967-017-1214-8
_version_ 1783238436443914240
author Li, Liang
Duan, Mubing
Chen, Weisan
Jiang, An
Li, Xiaoming
Yang, Jun
Li, Zongfang
author_facet Li, Liang
Duan, Mubing
Chen, Weisan
Jiang, An
Li, Xiaoming
Yang, Jun
Li, Zongfang
author_sort Li, Liang
collection PubMed
description The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis.
format Online
Article
Text
id pubmed-5442653
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54426532017-05-25 The spleen in liver cirrhosis: revisiting an old enemy with novel targets Li, Liang Duan, Mubing Chen, Weisan Jiang, An Li, Xiaoming Yang, Jun Li, Zongfang J Transl Med Review The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the development of portal hypertension. These splenic abnormalities correlate with and have been postulated to facilitate the progression of liver fibrosis to cirrhosis, although precise mechanisms remain poorly understood. In this review, we summarize the literature to highlight the mechanistic contributions of splenomegaly and hypersplenism to the development of liver cirrhosis, focusing on three key aspects: hepatic fibrogenesis, hepatic immune microenvironment dysregulation and liver regeneration. We conclude with a discussion of the possible therapeutic strategies for modulating splenic abnormalities, including the novel potential usage of nanomedicine in non-surgically targetting splenic disorders for the treatment of liver cirrhosis. BioMed Central 2017-05-23 /pmc/articles/PMC5442653/ /pubmed/28535799 http://dx.doi.org/10.1186/s12967-017-1214-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Liang
Duan, Mubing
Chen, Weisan
Jiang, An
Li, Xiaoming
Yang, Jun
Li, Zongfang
The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title_full The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title_fullStr The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title_full_unstemmed The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title_short The spleen in liver cirrhosis: revisiting an old enemy with novel targets
title_sort spleen in liver cirrhosis: revisiting an old enemy with novel targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442653/
https://www.ncbi.nlm.nih.gov/pubmed/28535799
http://dx.doi.org/10.1186/s12967-017-1214-8
work_keys_str_mv AT liliang thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT duanmubing thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT chenweisan thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT jiangan thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT lixiaoming thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT yangjun thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT lizongfang thespleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT liliang spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT duanmubing spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT chenweisan spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT jiangan spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT lixiaoming spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT yangjun spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets
AT lizongfang spleeninlivercirrhosisrevisitinganoldenemywithnoveltargets