Cargando…

Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno‐Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor‐β Gene Delivery

Transplantation of genetically modified peripheral blood aspirates that carry chondrogenically competent progenitor cells may offer new, convenient tools to treat articular cartilage lesions compared with the more complex and invasive application of bone marrow concentrates or of bone marrow‐derived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frisch, Janina, Orth, Patrick, Venkatesan, Jagadeesh Kumar, Rey‐Rico, Ana, Schmitt, Gertrud, Kohn, Dieter, Madry, Henning, Cucchiarini, Magali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Translational Research Articles and Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442727/ https://www.ncbi.nlm.nih.gov/pubmed/28170175 http://dx.doi.org/10.5966/sctm.2016-0149

Ejemplares similares

Peripheral blood aspirates overexpressing IGF‐I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes
por: Frisch, Janina, et al.
Publicado: (2017)

TGF‐β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2017)

Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates
por: Tao, Ke, et al.
Publicado: (2017)

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
por: Frisch, Janina, et al.
Publicado: (2014)

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2012)

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2013)

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells
por: Tao, Ke, et al.
Publicado: (2016)

Current perspectives in stem cell research for knee cartilage repair
por: Orth, Patrick, et al.
Publicado: (2014)

Cytotoxic effects of different mouthwash solutions on primary human articular chondrocytes and normal human articular cartilage – an in vitro study
por: Cai, Xiaoyu, et al.
Publicado: (2023)

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
por: Daniels, Oliver, et al.
Publicado: (2019)

Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2020)

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model
por: Rey-Rico, Ana, et al.
Publicado: (2017)

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2018)

Clinical potential and challenges of using genetically modified cells for articular cartilage repair
por: Madry, Henning, et al.
Publicado: (2011)

Subchondral drilling for articular cartilage repair: a systematic review of translational research
por: Gao, Liang, et al.
Publicado: (2018)

rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
por: Madry, Henning, et al.
Publicado: (2012)

Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration
por: Liu, Wei, et al.
Publicado: (2022)

Gene Therapy for Cartilage Repair
por: Madry, Henning, et al.
Publicado: (2011)

New trends in articular cartilage repair
por: Cucchiarini, Magali, et al.
Publicado: (2015)

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?
por: Velot, Émilie, et al.
Publicado: (2021)

Translational applications of photopolymerizable hydrogels for cartilage repair
por: Meng, Weikun, et al.
Publicado: (2019)

Scaffold-Mediated Gene Delivery for Osteochondral Repair
por: Madry, Henning, et al.
Publicado: (2020)

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
por: Madry, Henning, et al.
Publicado: (2017)

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

Advances in Human Mitochondria-Based Therapies
por: Zhong, Gang, et al.
Publicado: (2022)

Joint Cartilage in Long-Duration Spaceflight
por: Ganse, Bergita, et al.
Publicado: (2022)

Cyst formation in the subchondral bone following cartilage repair
por: Gao, Liang, et al.
Publicado: (2020)

Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair
por: Gao, Liang, et al.
Publicado: (2017)

Small-Diameter Subchondral Drilling Improves DNA and Proteoglycan Content of the Cartilaginous Repair Tissue in a Large Animal Model of a Full-Thickness Chondral Defect
por: Orth, Patrick, et al.
Publicado: (2020)

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Meng, Weikun, et al.
Publicado: (2020)

Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
por: Urich, Jonas, et al.
Publicado: (2020)

Advanced Gene Therapy Strategies for the Repair of ACL Injuries
por: Amini, Mahnaz, et al.
Publicado: (2022)

rAAV TGF-β and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts
por: Amini, Mahnaz, et al.
Publicado: (2023)

A novel algorithm for a precise analysis of subchondral bone alterations
por: Gao, Liang, et al.
Publicado: (2016)

Cyclodextrin Cationic Polymer-Based Nanoassemblies to Manage Inflammation by Intra-Articular Delivery Strategies
por: Cordaro, Annalaura, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ta6gsa4g44rdlr9pdnl1itr8bc