Are Mesenchymal Stem Cells So Bloody Great After All?

This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specif...

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Detalles Bibliográficos
Autores principales: Marfy‐Smith, Stephanie J., Clarkin, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442748/
https://www.ncbi.nlm.nih.gov/pubmed/28170195
http://dx.doi.org/10.5966/sctm.2016-0026
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author Marfy‐Smith, Stephanie J.
Clarkin, Claire E.
author_facet Marfy‐Smith, Stephanie J.
Clarkin, Claire E.
author_sort Marfy‐Smith, Stephanie J.
collection PubMed
description This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specific MSC populations (including bone marrow MSCs), their paracrine activity, tissue heterogeneity, and endothelial cell interactions. Also discussed are what could lead to contrasting effects of the influence of MSCs in regulating angiogenesis, pointing to some negative effects of these cells. In conclusion, this article highlights important aspects of MSC behavior within the perspective of translational medicine applications. Stem Cells Translational Medicine 2017;6:3–6
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spelling pubmed-54427482017-06-15 Are Mesenchymal Stem Cells So Bloody Great After All? Marfy‐Smith, Stephanie J. Clarkin, Claire E. Stem Cells Transl Med Perspectives This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specific MSC populations (including bone marrow MSCs), their paracrine activity, tissue heterogeneity, and endothelial cell interactions. Also discussed are what could lead to contrasting effects of the influence of MSCs in regulating angiogenesis, pointing to some negative effects of these cells. In conclusion, this article highlights important aspects of MSC behavior within the perspective of translational medicine applications. Stem Cells Translational Medicine 2017;6:3–6 John Wiley and Sons Inc. 2016-09-09 2017-01 /pmc/articles/PMC5442748/ /pubmed/28170195 http://dx.doi.org/10.5966/sctm.2016-0026 Text en © 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Marfy‐Smith, Stephanie J.
Clarkin, Claire E.
Are Mesenchymal Stem Cells So Bloody Great After All?
title Are Mesenchymal Stem Cells So Bloody Great After All?
title_full Are Mesenchymal Stem Cells So Bloody Great After All?
title_fullStr Are Mesenchymal Stem Cells So Bloody Great After All?
title_full_unstemmed Are Mesenchymal Stem Cells So Bloody Great After All?
title_short Are Mesenchymal Stem Cells So Bloody Great After All?
title_sort are mesenchymal stem cells so bloody great after all?
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442748/
https://www.ncbi.nlm.nih.gov/pubmed/28170195
http://dx.doi.org/10.5966/sctm.2016-0026
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