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Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective
Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades, substantial cumulative toxicity...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442770/ https://www.ncbi.nlm.nih.gov/pubmed/28186688 http://dx.doi.org/10.1002/sctm.16-0358 |
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author | Yolcu, Esma S. Shirwan, Haval Askenasy, Nadir |
author_facet | Yolcu, Esma S. Shirwan, Haval Askenasy, Nadir |
author_sort | Yolcu, Esma S. |
collection | PubMed |
description | Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades, substantial cumulative toxicity of combined hematopoietic and tissue transplants precludes wide clinical implementation. Tolerance is an active immunological process that includes both peripheral and central mechanisms of mutual education of coresident donor and host immune systems. The major stages include sequential suppression of early alloreactivity, establishment of hematopoietic chimerism and suppressor cells that sustain the state of tolerance, with significant mechanistic and temporal overlap along the tolerization process. Efforts to devise less toxic transplant strategies by reduction of preparatory conditioning focus on modulation rather than deletion of residual host immunity and early reinstitution of regulatory subsets at the central and peripheral levels. Stem Cells Translational Medicine 2017;6:700–712 |
format | Online Article Text |
id | pubmed-5442770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54427702017-06-15 Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective Yolcu, Esma S. Shirwan, Haval Askenasy, Nadir Stem Cells Transl Med Perspectives Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades, substantial cumulative toxicity of combined hematopoietic and tissue transplants precludes wide clinical implementation. Tolerance is an active immunological process that includes both peripheral and central mechanisms of mutual education of coresident donor and host immune systems. The major stages include sequential suppression of early alloreactivity, establishment of hematopoietic chimerism and suppressor cells that sustain the state of tolerance, with significant mechanistic and temporal overlap along the tolerization process. Efforts to devise less toxic transplant strategies by reduction of preparatory conditioning focus on modulation rather than deletion of residual host immunity and early reinstitution of regulatory subsets at the central and peripheral levels. Stem Cells Translational Medicine 2017;6:700–712 John Wiley and Sons Inc. 2017-01-03 2017-03 /pmc/articles/PMC5442770/ /pubmed/28186688 http://dx.doi.org/10.1002/sctm.16-0358 Text en © 2017 The Authors stemcellstranslationalmedicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Perspectives Yolcu, Esma S. Shirwan, Haval Askenasy, Nadir Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title | Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title_full | Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title_fullStr | Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title_full_unstemmed | Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title_short | Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective |
title_sort | mechanisms of tolerance induction by hematopoietic chimerism: the immune perspective |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442770/ https://www.ncbi.nlm.nih.gov/pubmed/28186688 http://dx.doi.org/10.1002/sctm.16-0358 |
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