Cargando…

A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis

Inflammation plays a pivotal role in the initiation and progression of atherosclerosis (ATH). Due to their potent immunomodulatory properties, mesenchymal stromal cells (MSCs) are evaluated as therapeutic tools in ATH and other chronic inflammatory disorders. Aging reduces MSCs immunopotency potenti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kizilay Mancini, Özge, Lora, Maximilien, Shum‐Tim, Dominique, Nadeau, Stephanie, Rodier, Francis, Colmegna, Inés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Translational Research Articles and Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442842/ https://www.ncbi.nlm.nih.gov/pubmed/28194905 http://dx.doi.org/10.1002/sctm.16-0221

Ejemplares similares

Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
por: Kizilay Mancini, Ozge, et al.
Publicado: (2015)

Erratum to: Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression
por: Mancini, Ozge Kizilay, et al.
Publicado: (2017)

CD26 is a senescence marker associated with reduced immunopotency of human adipose tissue-derived multipotent mesenchymal stromal cells
por: Psaroudis, Rose Triantafillia, et al.
Publicado: (2022)

Optimized reagents for immunopotency assays on mesenchymal stromal cells for clinical use
por: Torrents, Sílvia, et al.
Publicado: (2023)

Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis
por: O'Hagan-Wong, Kelsey, et al.
Publicado: (2016)

Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo
por: Cheng, Anastasia, et al.
Publicado: (2020)

Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?
por: Kiselevskii, M. V., et al.
Publicado: (2021)

MSC - targets for atherosclerosis therapy
por: Colmegna, Ines, et al.
Publicado: (2018)

NAD(+) metabolism governs the proinflammatory senescence-associated secretome
por: Nacarelli, Timothy, et al.
Publicado: (2019)

Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques
por: Xu, Fang, et al.
Publicado: (2022)

Ursodeoxycholic acid attenuates the expression of proinflammatory cytokines in periodontal cells
por: Talebian, Reza, et al.
Publicado: (2020)

Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells
por: Fabian, I, et al.
Publicado: (2006)

Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis
por: Lu, Tianyuan, et al.
Publicado: (2019)

A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome
por: Dong, Feng, et al.
Publicado: (2017)

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
por: Hinterdobler, Julia, et al.
Publicado: (2021)

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile
por: García-Bernal, David, et al.
Publicado: (2020)

Secretome of Stromal Cancer-Associated Fibroblasts (CAFs): Relevance in Cancer
por: Mishra, Deepshikha, et al.
Publicado: (2023)

Towards standardization of human adipose-derived stromal cells secretomes
por: Pinheiro-Machado, Erika, et al.
Publicado: (2023)

Renal cancer secretome induces migration of mesenchymal stromal cells
por: Popławski, Piotr, et al.
Publicado: (2023)

Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes
por: Satani, Nikunj, et al.
Publicado: (2020)

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness
por: Yu, Emma P.K., et al.
Publicado: (2017)

The Pathogenesis of Cholelithiasis in the Light of Latest Investigations
por: Fronczak, Francis E.
Publicado: (1899)

Targeting ErbB3-mediated stromal–epithelial interactions in pancreatic ductal adenocarcinoma
por: Liles, J S, et al.
Publicado: (2011)

SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour
por: Pulkka, Olli-Pekka, et al.
Publicado: (2017)

Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE(−/−) Mice
por: Ulleryd, Marcus A., et al.
Publicado: (2014)

Proinflammatory protein signatures in cryptogenic and large artery atherosclerosis stroke
por: Holmegaard, Lukas, et al.
Publicado: (2020)

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin
por: Colmegna, B, et al.
Publicado: (2015)

Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas
por: Farace, P, et al.
Publicado: (2009)

Dissection of stromal and cancer cell-derived signals in melanoma xenografts before and after treatment with DMXAA
por: Henare, K, et al.
Publicado: (2012)

microRNA expression signatures of gastrointestinal stromal tumours: associations with imatinib resistance and patient outcome
por: Akçakaya, P, et al.
Publicado: (2014)

Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells
por: Kaw, Kaveeta, et al.
Publicado: (2023)

Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease
por: Mendes‐Pinheiro, Bárbara, et al.
Publicado: (2018)

A nanocomposite hydrogel delivery system for mesenchymal stromal cell secretome
por: Shoma Suresh, K., et al.
Publicado: (2020)

Proteomic Profiling of the Human Fetal Multipotent Mesenchymal Stromal Cells Secretome
por: Lobov, Arseniy A., et al.
Publicado: (2020)

Mesenchymal Stromal Cell Secretome Is Affected by Tissue Source and Donor Age
por: Turlo, Agnieszka J, et al.
Publicado: (2023)

Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome
por: Arrell, D. Kent, et al.
Publicado: (2021)

Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine
por: Dudley, A C, et al.
Publicado: (2008)

Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease
por: Teixeira, Fábio G., et al.
Publicado: (2016)

Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL
por: Rikhof, B, et al.
Publicado: (2008)

Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma
por: Oguejiofor, K, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7bdihct4hkhdjghhncs83qgsbu