Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

BACKGROUND: Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast cancer patients with advanced disease. However, their functional role is not w...

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Detalles Bibliográficos
Autores principales: Bahreini, Amir, Li, Zheqi, Wang, Peilu, Levine, Kevin M., Tasdemir, Nilgun, Cao, Lan, Weir, Hazel M., Puhalla, Shannon L., Davidson, Nancy E., Stern, Andrew M., Chu, David, Park, Ben Ho, Lee, Adrian V., Oesterreich, Steffi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442865/
https://www.ncbi.nlm.nih.gov/pubmed/28535794
http://dx.doi.org/10.1186/s13058-017-0851-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442865/
https://www.ncbi.nlm.nih.gov/pubmed/28535794
http://dx.doi.org/10.1186/s13058-017-0851-4

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