Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models

BACKGROUND: Mutations in the estrogen receptor alpha (ERα) 1 gene (ESR1) are frequently detected in ER+ metastatic breast cancer, and there is increasing evidence that these mutations confer endocrine resistance in breast cancer patients with advanced disease. However, their functional role is not w...

Descripción completa

Detalles Bibliográficos
Autores principales: Bahreini, Amir, Li, Zheqi, Wang, Peilu, Levine, Kevin M., Tasdemir, Nilgun, Cao, Lan, Weir, Hazel M., Puhalla, Shannon L., Davidson, Nancy E., Stern, Andrew M., Chu, David, Park, Ben Ho, Lee, Adrian V., Oesterreich, Steffi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442865/
https://www.ncbi.nlm.nih.gov/pubmed/28535794
http://dx.doi.org/10.1186/s13058-017-0851-4

Ejemplares similares

Ejemplares similares