Dissecting microsatellite instability in colorectal cancer: one size does not fit all

Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might...

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Detalles Bibliográficos
Autores principales: Samstein, Robert M., Chan, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442871/
https://www.ncbi.nlm.nih.gov/pubmed/28539127
http://dx.doi.org/10.1186/s13073-017-0438-9
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author Samstein, Robert M.
Chan, Timothy A.
author_facet Samstein, Robert M.
Chan, Timothy A.
author_sort Samstein, Robert M.
collection PubMed
description Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might have consequences for the potential use of immunotherapy in MSI-positive cancers. See related research by Sveen et al. 10.1186/s13073-017-0434-0
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spelling pubmed-54428712017-05-25 Dissecting microsatellite instability in colorectal cancer: one size does not fit all Samstein, Robert M. Chan, Timothy A. Genome Med Research Highlight Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might have consequences for the potential use of immunotherapy in MSI-positive cancers. See related research by Sveen et al. 10.1186/s13073-017-0434-0 BioMed Central 2017-05-24 /pmc/articles/PMC5442871/ /pubmed/28539127 http://dx.doi.org/10.1186/s13073-017-0438-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Samstein, Robert M.
Chan, Timothy A.
Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title_full Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title_fullStr Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title_full_unstemmed Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title_short Dissecting microsatellite instability in colorectal cancer: one size does not fit all
title_sort dissecting microsatellite instability in colorectal cancer: one size does not fit all
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442871/
https://www.ncbi.nlm.nih.gov/pubmed/28539127
http://dx.doi.org/10.1186/s13073-017-0438-9
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