Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance

Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implications for immunosurve...

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Detalles Bibliográficos
Autores principales: Melief, Cornelis J. M., Kessler, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442872/
https://www.ncbi.nlm.nih.gov/pubmed/28539110
http://dx.doi.org/10.1186/s13073-017-0439-8
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author Melief, Cornelis J. M.
Kessler, Jan H.
author_facet Melief, Cornelis J. M.
Kessler, Jan H.
author_sort Melief, Cornelis J. M.
collection PubMed
description Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implications for immunosurveillance by T cells and translational value for immunotherapy.
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spelling pubmed-54428722017-05-25 Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance Melief, Cornelis J. M. Kessler, Jan H. Genome Med Comment Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implications for immunosurveillance by T cells and translational value for immunotherapy. BioMed Central 2017-05-24 /pmc/articles/PMC5442872/ /pubmed/28539110 http://dx.doi.org/10.1186/s13073-017-0439-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Melief, Cornelis J. M.
Kessler, Jan H.
Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title_full Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title_fullStr Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title_full_unstemmed Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title_short Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance
title_sort novel insights into the hla class i immunopeptidome and t-cell immunosurveillance
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442872/
https://www.ncbi.nlm.nih.gov/pubmed/28539110
http://dx.doi.org/10.1186/s13073-017-0439-8
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