In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor

BACKGROUND: Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The Sonic hedgehog (SHH) pathway is involved in vascular physiology. We sought to establish whether the SHH pathway has a role in pulmonary endothelial dysfunction in smokers. METHODS: The ex vivo end...

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Detalles Bibliográficos
Autores principales: Henno, Priscilla, Grassin-Delyle, Stanislas, Belle, Emeline, Brollo, Marion, Naline, Emmanuel, Sage, Edouard, Devillier, Philippe, Israël-Biet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442874/
https://www.ncbi.nlm.nih.gov/pubmed/28535764
http://dx.doi.org/10.1186/s12931-017-0590-1

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