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Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data

In diffuse optical tomography (DOT), overlapping and multidistance measurements are required to reconstruct depth-resolved images of oxy- ([Formula: see text]) and deoxy- (HHb) hemoglobin concentration changes occurring in the brain. These can be considered an indirect measure of brain activity, und...

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Autores principales: Brigadoi, Sabrina, Phan, Phong, Highton, David, Powell, Samuel, Cooper, Robert J., Hebden, Jeremy, Smith, Martin, Tachtsidis, Ilias, Elwell, Clare E., Gibson, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443419/
https://www.ncbi.nlm.nih.gov/pubmed/28560239
http://dx.doi.org/10.1117/1.NPh.4.2.021105
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author Brigadoi, Sabrina
Phan, Phong
Highton, David
Powell, Samuel
Cooper, Robert J.
Hebden, Jeremy
Smith, Martin
Tachtsidis, Ilias
Elwell, Clare E.
Gibson, Adam P.
author_facet Brigadoi, Sabrina
Phan, Phong
Highton, David
Powell, Samuel
Cooper, Robert J.
Hebden, Jeremy
Smith, Martin
Tachtsidis, Ilias
Elwell, Clare E.
Gibson, Adam P.
author_sort Brigadoi, Sabrina
collection PubMed
description In diffuse optical tomography (DOT), overlapping and multidistance measurements are required to reconstruct depth-resolved images of oxy- ([Formula: see text]) and deoxy- (HHb) hemoglobin concentration changes occurring in the brain. These can be considered an indirect measure of brain activity, under the assumption of intact neurovascular coupling. Broadband systems also allow changes in the redox state of cytochrome c oxidase (oxCCO) to be measured, which can be an important biomarker when neurovascular coupling is impaired. We used DOT to reconstruct images of [Formula: see text] , [Formula: see text] , and [Formula: see text] from data acquired with a broadband system. Four healthy volunteers were measured while performing a visual stimulation task (4-Hz inverting checkerboard). The broadband system was configured to allow multidistance and overlapping measurements of the participants’ visual cortex with 32 channels. A multispectral approach was employed to reconstruct changes in concentration of the three chromophores during the visual stimulation. A clear and focused activation was reconstructed in the left occipital cortex of all participants. The difference between the residuals of the three-chromophore model and of the two-chromophore model (recovering only [Formula: see text] and [Formula: see text]) exhibits a spectrum similar to that of oxCCO. These results form a basis for further studies aimed to further optimize image reconstruction of [Formula: see text].
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spelling pubmed-54434192017-05-30 Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data Brigadoi, Sabrina Phan, Phong Highton, David Powell, Samuel Cooper, Robert J. Hebden, Jeremy Smith, Martin Tachtsidis, Ilias Elwell, Clare E. Gibson, Adam P. Neurophotonics Special Section on Functional Near Infrared Spectroscopy, Part 1 In diffuse optical tomography (DOT), overlapping and multidistance measurements are required to reconstruct depth-resolved images of oxy- ([Formula: see text]) and deoxy- (HHb) hemoglobin concentration changes occurring in the brain. These can be considered an indirect measure of brain activity, under the assumption of intact neurovascular coupling. Broadband systems also allow changes in the redox state of cytochrome c oxidase (oxCCO) to be measured, which can be an important biomarker when neurovascular coupling is impaired. We used DOT to reconstruct images of [Formula: see text] , [Formula: see text] , and [Formula: see text] from data acquired with a broadband system. Four healthy volunteers were measured while performing a visual stimulation task (4-Hz inverting checkerboard). The broadband system was configured to allow multidistance and overlapping measurements of the participants’ visual cortex with 32 channels. A multispectral approach was employed to reconstruct changes in concentration of the three chromophores during the visual stimulation. A clear and focused activation was reconstructed in the left occipital cortex of all participants. The difference between the residuals of the three-chromophore model and of the two-chromophore model (recovering only [Formula: see text] and [Formula: see text]) exhibits a spectrum similar to that of oxCCO. These results form a basis for further studies aimed to further optimize image reconstruction of [Formula: see text]. Society of Photo-Optical Instrumentation Engineers 2017-05-24 2017-04 /pmc/articles/PMC5443419/ /pubmed/28560239 http://dx.doi.org/10.1117/1.NPh.4.2.021105 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Special Section on Functional Near Infrared Spectroscopy, Part 1
Brigadoi, Sabrina
Phan, Phong
Highton, David
Powell, Samuel
Cooper, Robert J.
Hebden, Jeremy
Smith, Martin
Tachtsidis, Ilias
Elwell, Clare E.
Gibson, Adam P.
Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title_full Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title_fullStr Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title_full_unstemmed Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title_short Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data
title_sort image reconstruction of oxidized cerebral cytochrome c oxidase changes from broadband near-infrared spectroscopy data
topic Special Section on Functional Near Infrared Spectroscopy, Part 1
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443419/
https://www.ncbi.nlm.nih.gov/pubmed/28560239
http://dx.doi.org/10.1117/1.NPh.4.2.021105
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