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Membrane protein contact and structure prediction using co-evolution in conjunction with machine learning
De novo membrane protein structure prediction is limited to small proteins due to the conformational search space quickly expanding with length. Long-range contacts (24+ amino acid separation)–residue positions distant in sequence, but in close proximity in the structure, are arguably the most effec...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443516/ https://www.ncbi.nlm.nih.gov/pubmed/28542325 http://dx.doi.org/10.1371/journal.pone.0177866 |