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Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before tar...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443784/ https://www.ncbi.nlm.nih.gov/pubmed/28539601 http://dx.doi.org/10.1038/s41598-017-02616-0 |
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author | Spadone, Sara Sestieri, Carlo Baldassarre, Antonello Capotosto, Paolo |
author_facet | Spadone, Sara Sestieri, Carlo Baldassarre, Antonello Capotosto, Paolo |
author_sort | Spadone, Sara |
collection | PubMed |
description | The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before target presentation. Previous studies from our group showed that the anticipatory alpha ERD can be modulated when magnetic stimulation is delivered over specific cortical regions during a variety of cognitive tasks. In this study we investigate the temporal dynamics of the anticipatory alpha ERD and test whether the magnetic stimulation produces either a general attenuation or an interruption of the typical development of alpha ERD. We report that, during a semantic decision task, rTMS over left AG, a region previously associated to semantic memory retrieval, shortened the peak latency and decreased the peak amplitude of the anticipatory alpha de-synchronization as compared to both active (left IPS) and non-active (Sham) TMS conditions. These results, while supporting the causal role of the left AG in the anticipation of a semantic decision task, suggest that magnetic interference not simply reduces the mean amplitude of anticipatory alpha ERD but also interrupts its typical temporal evolution in paradigms employing fixed cue-target intervals. |
format | Online Article Text |
id | pubmed-5443784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54437842017-05-26 Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions Spadone, Sara Sestieri, Carlo Baldassarre, Antonello Capotosto, Paolo Sci Rep Article The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before target presentation. Previous studies from our group showed that the anticipatory alpha ERD can be modulated when magnetic stimulation is delivered over specific cortical regions during a variety of cognitive tasks. In this study we investigate the temporal dynamics of the anticipatory alpha ERD and test whether the magnetic stimulation produces either a general attenuation or an interruption of the typical development of alpha ERD. We report that, during a semantic decision task, rTMS over left AG, a region previously associated to semantic memory retrieval, shortened the peak latency and decreased the peak amplitude of the anticipatory alpha de-synchronization as compared to both active (left IPS) and non-active (Sham) TMS conditions. These results, while supporting the causal role of the left AG in the anticipation of a semantic decision task, suggest that magnetic interference not simply reduces the mean amplitude of anticipatory alpha ERD but also interrupts its typical temporal evolution in paradigms employing fixed cue-target intervals. Nature Publishing Group UK 2017-05-24 /pmc/articles/PMC5443784/ /pubmed/28539601 http://dx.doi.org/10.1038/s41598-017-02616-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Spadone, Sara Sestieri, Carlo Baldassarre, Antonello Capotosto, Paolo Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title | Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title_full | Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title_fullStr | Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title_full_unstemmed | Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title_short | Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions |
title_sort | temporal dynamics of tms interference over preparatory alpha activity during semantic decisions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443784/ https://www.ncbi.nlm.nih.gov/pubmed/28539601 http://dx.doi.org/10.1038/s41598-017-02616-0 |
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