The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium falciparum strain is exposed to ART derivatives such as dihyd...

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Detalles Bibliográficos
Autores principales: Dembele, L., Ang, X., Chavchich, M., Bonamy, G. M. C., Selva, J. J., Lim, M. Yi-Xiu, Bodenreider, C., Yeung, B. K. S., Nosten, F., Russell, B. M., Edstein, M. D., Straimer, J., Fidock, D. A., Diagana, T. T., Bifani, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443816/
https://www.ncbi.nlm.nih.gov/pubmed/28539634
http://dx.doi.org/10.1038/s41598-017-02440-6

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