Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation

Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to contro...

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Detalles Bibliográficos
Autores principales: Atchade, Enora, Jean-Baptiste, Sylvain, Houzé, Sandrine, Chabut, Claire, Massias, Laurent, Castier, Yves, Brugière, Olivier, Mal, Hervé, Montravers, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443963/
https://www.ncbi.nlm.nih.gov/pubmed/28560131
http://dx.doi.org/10.1016/j.mmcr.2017.05.002
Descripción
Sumario:Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and caspofungin for 23 days, the patient developed massive hemoptysis leading to death. The authors report the clinical features and treatment of this case.

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