Tat-haFGF(14–154) Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway

Acid fibroblast growth factor (aFGF) has shown neuroprotection in Alzheimer’s disease (AD) models in previous studies, yet its mechanism is still uncertain. Here we report that the efficacy of Tat-haFGF(14–154) is markedly increased when loaded cationic liposomes for intranasal delivery are intranas...

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Detalles Bibliográficos
Autores principales: Meng, Tian, Cao, Qin, Lei, Peng, Bush, Ashley I., Xiang, Qi, Su, Zhijian, He, Xiang, Rogers, Jack T., Chiu, Ing-Ming, Zhang, Qihao, Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443968/
https://www.ncbi.nlm.nih.gov/pubmed/28624220
http://dx.doi.org/10.1016/j.omtn.2017.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443968/
https://www.ncbi.nlm.nih.gov/pubmed/28624220
http://dx.doi.org/10.1016/j.omtn.2017.05.004

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