Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate risk genes within these loci for their ability to...

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Detalles Bibliográficos
Autores principales: Dourlen, P, Fernandez-Gomez, F J, Dupont, C, Grenier-Boley, B, Bellenguez, C, Obriot, H, Caillierez, R, Sottejeau, Y, Chapuis, J, Bretteville, A, Abdelfettah, F, Delay, C, Malmanche, N, Soininen, H, Hiltunen, M, Galas, M-C, Amouyel, P, Sergeant, N, Buée, L, Lambert, J-C, Dermaut, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444024/
https://www.ncbi.nlm.nih.gov/pubmed/27113998
http://dx.doi.org/10.1038/mp.2016.59

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