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Opposing effects of prostaglandin E(2) receptors EP3 and EP4 on mouse and human β-cell survival and proliferation

OBJECTIVE: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce the production of the inflammatory signaling molecule Prostaglandin E(2) (PGE(2)) in islets. The effects of PGE(2) are mediated by its four receptors, E-Prostanoid Receptors 1-4 (EP1-4). EP3 and EP4 pl...

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Detalles Bibliográficos
Autores principales:	Carboneau, Bethany A., Allan, Jack A., Townsend, Shannon E., Kimple, Michelle E., Breyer, Richard M., Gannon, Maureen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444094/ https://www.ncbi.nlm.nih.gov/pubmed/28580285 http://dx.doi.org/10.1016/j.molmet.2017.04.002

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