Cargando…

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis

OBJECTIVE: Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long-acting analogue reduces body weight and improves lipid profiles of participants in clinical studies; however, the intracellular mechanisms mediating these effects are po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mottillo, Emilio P., Desjardins, Eric M., Fritzen, Andreas M., Zou, Vito Z., Crane, Justin D., Yabut, Julian M., Kiens, Bente, Erion, Derek M., Lanba, Adhiraj, Granneman, James G., Talukdar, Saswata, Steinberg, Gregory R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444097/ https://www.ncbi.nlm.nih.gov/pubmed/28580278 http://dx.doi.org/10.1016/j.molmet.2017.04.001

Ejemplares similares

Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
por: Jones, Jessica E. C., et al.
Publicado: (2017)

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion
por: Veprik, Anna, et al.
Publicado: (2022)

Acetyl-CoA Carboxylase (ACC) Inhibitor, CP640186, Effectively Inhibited Dengue Virus (DENV) Infection via Regulating ACC Phosphorylation
por: Wu, Wenyu, et al.
Publicado: (2022)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

Efficacy and safety of acetyl-CoA carboxylase (ACC) inhibitors in the treatment of nonalcoholic steatohepatitis (NASH): A protocol for systematic review
por: Xu, Liubin, et al.
Publicado: (2022)

Two Independent Plastid accD Transfers to the Nuclear Genome of Gnetum and Other Insights on Acetyl-CoA Carboxylase Evolution in Gymnosperms
por: Sudianto, Edi, et al.
Publicado: (2019)

Chemical Genetics of Acetyl-CoA Carboxylases
por: Zu, Xuyu, et al.
Publicado: (2013)

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
por: Lundsgaard, Anne-Marie, et al.
Publicado: (2016)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK
por: Gross, Angelina S., et al.
Publicado: (2019)

The Importance of Fatty Acids as Nutrients during Post-Exercise Recovery
por: Lundsgaard, Anne-Marie, et al.
Publicado: (2020)

Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance
por: Karami, Kristophe J, et al.
Publicado: (2006)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
por: Jursík, Miroslav, et al.
Publicado: (2021)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
por: Galic, Sandra, et al.
Publicado: (2018)

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis
por: Matsumoto, Mitsuharu, et al.
Publicado: (2020)

Characterization of Acetyl-CoA Carboxylases in the Basal Dinoflagellate Amphidinium carterae
por: Haq, Saddef, et al.
Publicado: (2017)

Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase
por: Larson, Erica C., et al.
Publicado: (2020)

A Unique Presentation of 3-Methylcrotonyl-CoA Carboxylase Deficiency
por: Jagadish, Ashwin, et al.
Publicado: (2023)

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut
por: Peng, Zhenying, et al.
Publicado: (2023)

Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria
por: Bazet Lyonnet, Bernardo, et al.
Publicado: (2014)

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
por: Guilherme, Adilson, et al.
Publicado: (2023)

A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
por: Mottillo, Emilio P., et al.
Publicado: (2023)

A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase
por: Bozaquel-Morais, Bruno L., et al.
Publicado: (2017)

Correction: Pleiotropic Effect of AccD5 and AccE5 Depletion in Acyl-Coenzyme A Carboxylase Activity and in Lipid Biosynthesis in Mycobacteria
por: Lyonnet, Bernardo Bazet, et al.
Publicado: (2020)

Crystal structure of the essential biotin‐dependent carboxylase AccA3 from Mycobacterium tuberculosis
por: Bennett, Matthew, et al.
Publicado: (2017)

Association between Phosphorylated AMP-Activated Protein Kinase and Acetyl-CoA Carboxylase Expression and Outcome in Patients with Squamous Cell Carcinoma of the Head and Neck
por: Su, Ying-Wen, et al.
Publicado: (2014)

Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
por: Park, Keerang, et al.
Publicado: (1993)

Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis
por: Unissa, Ameeruddin Nusrath, et al.
Publicado: (2011)

Acetyl CoA Carboxylase 2 Is Dispensable for CD8(+) T Cell Responses
por: Lee, Jang Eun, et al.
Publicado: (2015)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2016)

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation
por: Wei, Jia, et al.
Publicado: (2017)

Acetyl-CoA carboxylase inhibitors in non-alcoholic steatohepatitis: Is there a benefit?
por: Neokosmidis, Georgios, et al.
Publicado: (2021)

Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase
por: Bough, Raven, et al.
Publicado: (2022)

Influence of Nutrient (NPK) Factors on Growth, and Pharmacodynamic Component Biosynthesis of Atractylodes chinensis: An Insight on Acetyl-CoA Carboxylase (ACC), 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR), and Farnesyl Pyrophosphate Synthase (FPPS) Signaling Responses
por: Sun, Jin, et al.
Publicado: (2022)

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
por: Ray, Lauren, et al.
Publicado: (2016)

Inhibition of acetyl-CoA carboxylase by spirotetramat causes growth arrest and lipid depletion in nematodes
por: Gutbrod, Philipp, et al.
Publicado: (2020)

Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis
por: Scott, Kristen E. N., et al.
Publicado: (2012)

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
por: Bernardo, Barbara, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_86fb63hff2al92r4bj7atvogru