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NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells

OBJECTIVE: The glucose stimulation of insulin secretion (GSIS) by pancreatic β-cells critically depends on increased production of metabolic coupling factors, including NADPH. Nicotinamide nucleotide transhydrogenase (NNT) typically produces NADPH at the expense of NADH and ΔpH in energized mitochon...

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Detalles Bibliográficos
Autores principales:	Santos, Laila R.B., Muller, Carole, de Souza, Arnaldo H., Takahashi, Hilton K., Spégel, Peter, Sweet, Ian R., Chae, Heeyoung, Mulder, Hindrik, Jonas, Jean-Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444111/ https://www.ncbi.nlm.nih.gov/pubmed/28580284 http://dx.doi.org/10.1016/j.molmet.2017.04.004

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